Accounting for the Potential of Overdispersion in Estimation of the Time-varying Reproduction Number.
The time-varying reproduction number, Rt, is commonly used to monitor the transmissibility of an infectious disease during an epidemic, but standard methods for estimating Rt seldom account for the impact of overdispersion on transmission. We developed a negative binomial framework to estimate Rt and a time-varying dispersion parameter (kt). We applied the framework to COVID-19 incidence data in Hong Kong in 2020 and 2021. We conducted a simulation study to compare the performance of our model with the conventional Poisson-based approach. Our framework estimated an Rt peaking around 4 (95% credible interval = 3. 13, 4. 30), similar to that from the Poisson approach but with a better model fit. Our approach further estimated kt
The time-varying reproduction number, Rt, is commonly used to monitor the transmissibility of an infectious disease during an epidemic, but standard methods for estimating Rt seldom account for the impact of overdispersion on transmission. We developed a negative binomial framework to estimate Rt and a time-varying dispersion parameter (kt). We applied the framework to COVID-19 incidence data in Hong Kong in 2020 and 2021. We conducted a simulation study to compare the performance of our model with the conventional Poisson-based approach. Our framework estimated an Rt peaking around 4 (95% credible interval = 3. 13, 4. 30), similar to that from the Poisson approach but with a better model fit. Our approach further estimated kt
Original Source Link: https://www.ncbi.nlm.nih.gov/pubmed/36722802
Original Source Link: https://www.ncbi.nlm.nih.gov/pubmed/36722802
