Publication date: Sep 01, 2023

COVID-19 vaccines are highly immunogenic but cardiovascular effects of these vaccines have not been properly elucidated. To determine impact of COVID-19 vaccination on mortality following acute myocardial infarction (AMI). This was a single center retrospective observation study among patients with AMI enrolled in the the North India ST-Elevation Myocardial Infarction (NORIN-STEMI) registry. In all the enrolled patients, data regarding patient’s vaccination status including details on type of vaccine, date of vaccination and adverse effects were obtained. All enrolled subjects were followed up for a period of six months. The primary outcome of the study was all-cause mortality both at one month and at six months of follow-up. Propensity-weighted score logistic regression model using inverse probability of treatment weighting was used to determine the impact of vaccination status on all-cause mortality. A total of 1578 subjects were enrolled in the study of whom 1086(68. 8%) were vaccinated against COVID-19 while 492(31. 2%) were unvaccinated. Analysis of the temporal trends of occurrence of AMI post vaccination did not show a specific clustering of AMI at any particular time. On 30-day follow-up, all-cause mortality occurred in 201(12. 7%) patients with adjusted odds of mortality being significantly lower in vaccinated group (adjusted odds ratio[aOR]: 0. 58, 95% CI: 0. 47-0. 71). Similarly, at six months of follow-up, vaccinated AMI group had lower odds of mortality(aOR: 0. 54, 95% CI: 0. 44 to 0. 65) as compared to non-vaccinated group. COVID-19 vaccines have shown to decrease all-cause mortality at 30 days and six months following AMI.

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