Enterococcus faecium Empyema Following Extracorporeal Membrane Oxygenation for COVID-19 Acute Respiratory Distress Syndrome.

Publication date: Aug 01, 2023

A 33-year-old male with severe COVID-19 required prolonged veno-venous extracorporeal membrane oxygenation (ECMO) support. Following decannulation, he developed an Enterococcus faecium empyema. Tube thoracostomy and broad-spectrum antibiotics were initiated, followed by an unsuccessful attempt at pleural irrigation with saline, given the patient had an increased risk of bleeding due to the concomitant requirement for systemic anticoagulation. Subsequently, intrapleural tissue plasminogen activator (tPA) and recombinant human Dornase alfa (DNase) were safely administered with the resolution of empyema. Enterococcus faecium is an uncommon cause of pleural empyema and, to our knowledge, has not previously been reported to be associated with COVID-19 or ECMO.

Concepts Keywords
Anticoagulation anticoagulation
Enterococcus covid-19
Old ecmo
Recombinant enterococcus faecium
Thoracostomy pleural empyema
veno-venous ecmo
vv ecmo


Type Source Name
drug DRUGBANK Enterococcus faecium
disease MESH Empyema
disease MESH COVID-19
disease MESH Acute Respiratory Distress Syndrome
disease MESH bleeding
drug DRUGBANK Alteplase
drug DRUGBANK Dornase alfa
disease MESH pleural empyema

Original Article

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