Cellular Stress Responses against Coronavirus Infection: A Means of the Innate Antiviral Defense.

Publication date: Sep 08, 2023

Cellular stress responses are crucial for maintaining cellular homeostasis. Stress granules (SGs), activated by eIF2α kinases in response to various stimuli, play a pivotal role in dealing with diverse stress conditions. Viral infection, as one kind of cellular stress, triggers specific cellular programs aimed at overcoming virus-induced stresses. Recent studies have revealed that virus-derived stress responses are tightly linked to the host’s antiviral innate immunity. Virus infection-induced SGs act as platforms for antiviral sensors, facilitating the initiation of protective antiviral responses called “antiviral stress granules” (avSGs). However, many viruses, including coronaviruses, have evolved strategies to suppress avSG formation, thereby counteracting the host’s immune responses. This review discusses the intricate relationship between cellular stress responses and antiviral innate immunity, with a specific focus on coronaviruses. Furthermore, the diverse mechanisms employed by viruses to counteract avSGs are described.

Concepts Keywords
Antiviral antiviral stress granule
Biotechnol Coronavirus
Coronaviruses Interferon
Homeostasis RIG-I-like receptors
Protective toll-like receptors
virus immune evasion


Type Source Name
disease MESH Coronavirus Infection
disease MESH Viral infection
disease IDO host
disease VO Viruses

Original Article

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