Reconstructive cranial surgery for invasive and non-responsive mucormycosis.

Reconstructive cranial surgery for invasive and non-responsive mucormycosis.

Publication date: Sep 15, 2023

The incidence of mucormycosis showed a sharp rise during the COVID-19 pandemic in vulnerable populations like people with diabetes. Here, we report a case of mucormycosis of the frontal and ethmoid sinuses in a man in his mid-50s with a background of diabetes mellitus and COVID-19 infection requiring steroids and oxygen support. The infection had remained persistent despite initial debridement by functional endoscopic sinus surgery of the anterior frontal sinus wall and re-exploration, followed by debridement using the brow incision. The patient had received an entire course of systemic antifungal therapy during the postoperative period. A bifrontal craniotomy, excision of the supraorbital ridge and complete removal of bilateral frontal sinuses managed the persistent fungal infection. The defect was reconstructed with a custom-made three-dimensional-printed MRI-compatible titanium cranioplasty mesh. The patient had no signs of infection on the 9-month follow-up.

Concepts Keywords
50s COVID-19
Complete Diabetes
Diabetes Otolaryngology / ENT


Type Source Name
disease MESH mucormycosis
disease MESH COVID-19 pandemic
disease VO report
disease MESH diabetes mellitus
disease MESH infection
drug DRUGBANK Oxygen
disease MESH fungal infection
drug DRUGBANK Titanium

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