SARS-CoV-2: Current Tools to Fight COVID-19 ST-Elevation Myocardial Infarction.

SARS-CoV-2: Current Tools to Fight COVID-19 ST-Elevation Myocardial Infarction.

Publication date: Aug 01, 2023

The capacity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to wreak havoc on the inflammatory and coagulation pathways via the cytokine storm has led to over 6. 3 million fatalities globally. Based on recent data, the mechanism predominately involves the formation of microvascular thrombosis when pertaining to cardiovascular disease. However, a subset of coronavirus disease-2019 (COVID-19)-positive patients present emergently with acute ST-elevation myocardial infarction (STEMI) are found to have severe epicardial thrombosis which is refractory to traditional coronary revascularization. We have noted mortality in these patients presenting to our facility to be as high as 90% and all angiographically confirmed to have thrombus which was refractory to traditional therapy. We present a case series of COVID-19-positive patients presenting with STEMI found to have epicardial thrombus who were treated with different traditional STEMI therapies but with fatal outcomes. Other possible techniques including mechanical thrombectomy, optimizing traditional and nontraditional anticoagulation therapy with the use of early hemodynamic support may prove more efficacious to destroy thrombus and potentially improve mortality.

Concepts Keywords
Cardiovascular balloon pump
Coronavirus coronary stent
Fatal covid 19
Thrombectomy impella device
mechanical thrombectomy (mt)
myocardial infarction
percutaneous cardiac intervention


Type Source Name
disease MESH COVID-19
disease MESH Myocardial Infarction
disease VO Severe acute respiratory syndrome coronavirus 2
disease MESH cytokine storm
disease MESH thrombosis
disease MESH cardiovascular disease
pathway KEGG Coronavirus disease
disease MESH STEMI
disease IDO facility
disease MESH fatal outcomes
disease VO device
disease IDO intervention

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