Breastmilk from COVID-19 negative lactating mothers shows neutralizing activity against SARS-COV-2.

Breastmilk from COVID-19 negative lactating mothers shows neutralizing activity against SARS-COV-2.

Publication date: Sep 19, 2023

Breastmilk protects newborns from infections through specific and nonspecific compounds. This study investigated the neutralizing activity against SARS-CoV-2 of breastmilk from SARS-CoV-2 negative, unvaccinated mothers, and compared it to that from infected nursing mothers. We enrolled women after COVID-19 swab testing results upon maternity admission, and divided them into two groups: group A, COVID-19-positive mothers, and group B, negative mothers. Breastmilk was randomly sampled at 2, 7, and 20 days postpartum. We collected 19 samples for Group A and 41 for Group B. A microneutralization assay was used to determine the 50% neutralization (NT) titre. The presence of neutralizing antibodies was also determined. Group A had 100% neutralizing samples at 2 days postpartum (T0), declining 7 days postpartum (T1) and 20 days postpartum (T2). Group B samples exhibited neutralizing activity mostly at 7 days postpartum (T1) (90%). Negative mothers’ samples showed no correlation between NT titres and antibodies’ presence, suggesting that non-specific breastmilk components may exert antiviral action against SARS-CoV-2.

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Concepts Keywords
20days Activity
Antibodies Antibodies
Antiviral Breastmilk
Breastmilk Cov
Postpartum Covid


Type Source Name
disease MESH COVID-19
disease MESH infections
disease VO unvaccinated
disease IDO assay
drug DRUGBANK Coenzyme M
disease VO vaccinated
disease IDO infection
disease VO vaccination
disease VO Viruses
disease VO pregnant women
disease VO population
disease IDO history
disease VO dose
disease VO vaccine
disease MESH asymptomatic infection
disease IDO facility
disease VO USA
disease VO titer
disease VO time
pathway REACTOME Fatty acids
disease MESH viral infections
disease VO Human immunodeficiency virus

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