Chronic Spontaneous Urticaria Following mRNA COVID-19 Booster Vaccination at a Military Academy.

Chronic Spontaneous Urticaria Following mRNA COVID-19 Booster Vaccination at a Military Academy.

Publication date: Sep 19, 2023

Several adverse cutaneous reactions have been reported in the literature after SARS-CoV-2 vaccination with emerging reports on chronic spontaneous urticaria (CSU). However, there is little literature of chronic urticaria after COVID-19 boosters in a military population and the impact on operational readiness. We present a retrospective case series of CSU following Moderna COVID-19 booster vaccinations at the US Naval Academy (USNA). Demographics, clinical features, and impact on readiness were evaluated. Forty-nine students from the USNA were evaluated for urticaria after their third COVID-19 booster vaccination. Seventeen individuals were diagnosed with CSU. The median age was 20 years and predominantly male; the median time interval between vaccination and the onset of urticaria was 11 days. Out of 13 referred to Allergy, 7 patients had CU index performed and 2 were positive. Four patients received a second booster vaccination subsequently and did not have any exacerbation of symptoms. Symptoms were controlled with antihistamines, and none required immunomodulator or immunosuppressive therapies. All students were able to complete their commissioning, and none were referred for a medical board. In this series, USNA students who developed CSU after the mRNA COVID-19 Moderna booster vaccine did not have limitations from commissioning, duty status, or issues with subsequent COVID-19 vaccinations.

Concepts Keywords
11days Academy
20years Booster
Immunosuppressive Chronic
Male Covid
Urticaria Csu


Type Source Name
disease MESH Chronic Spontaneous Urticaria
disease MESH COVID-19
disease VO vaccination
disease VO population
disease MESH urticaria
disease VO time
disease MESH Allergy
disease VO vaccine

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