Virome of high-altitude canine digestive tract and genetic characterization of novel viruses potentially threatening human health.

Virome of high-altitude canine digestive tract and genetic characterization of novel viruses potentially threatening human health.

Publication date: Sep 19, 2023

The majority of currently emerging infectious illnesses are zoonotic infections, which have caused serious public health and economic implications. The development of viral metagenomics has helped us to explore unknown viruses. We collected 1,970 canine feces from Yushu and Guoluo in the plateau region of China for this study to do a metagenomics analysis of the viral community of the canine digestive tract. Our analysis identified 203 novel viruses, classified into 11 known families and 2 unclassified groups. These viruses include the hepatitis E virus, first identified in dogs, and the astrovirus, coronavirus, polyomavirus, and others. The relationship between the newly identified canine viruses and known viruses was investigated through the use of phylogenetic analysis. Furthermore, we demonstrated the cross-species transmission of viruses and predicted new viruses that may cause diseases in both humans and animals, providing technical support for the prevention and control of diseases caused by environmental pollution viruses. IMPORTANCE Most emerging infectious diseases are due to zoonotic disease agents. Because of their effects on the security of human or animal life, agriculture production, and food safety, zoonotic illnesses and livestock diseases are of worldwide significance. Because dogs are closely related to humans and domestic animals, they serve as one of the important links in the transmission of zoonotic and livestock diseases. Canines can contaminate the environment in which humans live such as water and soil through secretions, potentially altering the human gut microbiota or causing diseases. Our study enriched the viral community in the digestive tract microbiome of dogs and found types of viruses that threaten human health, providing technical support for the prevention and control of early warning of diseases caused by environmental contaminant viruses.

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Concepts Keywords
Astrovirus canine
China hepatitis E virus
Environmental phylogenetic
Genetic viral metagenomics
Illnesses viruses


Type Source Name
disease VO Viruses
disease MESH zoonotic infections
disease MESH emerging infectious diseases
disease IDO production
drug DRUGBANK Water
disease MESH hepatitis
disease IDO pathogen
disease MESH COVID 19
disease MESH avian influenza
disease VO volume
drug DRUGBANK Coenzyme M
drug DRUGBANK Medical air
disease VO Bacteria
disease VO Archaea
disease VO Fungi
disease VO Protozoa
disease IDO host
pathway REACTOME Metabolism
disease MESH lifestyle
disease MESH infectious diseases
disease VO efficient
disease VO effective
drug DRUGBANK Phosphate ion
disease IDO cell
disease VO USA
disease VO time
disease IDO quality
disease VO Gap
disease VO ORF
disease IDO algorithm
disease VO frequency
disease IDO process
disease VO Enterovirus
drug DRUGBANK Hyaluronic acid
disease MESH infection
disease MESH severe acute respiratory syndrome
disease MESH Middle East respiratory syndrome
disease VO vaccine
disease MESH immunocompromised patients
disease MESH heart diseases
disease VO Protoparvovirus
disease VO NS1
disease VO Feline panleukopenia virus
drug DRUGBANK Stavudine
disease MESH Rabies
disease IDO zoonosis
disease MESH influenza
drug DRUGBANK Dantron
disease IDO infectivity
disease VO effectiveness
disease VO population
disease MESH echinococcoses
drug DRUGBANK Troleandomycin
disease VO protocol
drug DRUGBANK Guanosine
disease VO pregnant women
disease VO organization
disease IDO replication
disease MESH pneumonia
drug DRUGBANK Carboxyamidotriazole
disease MESH viral infections
disease VO Canada

Original Article

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