Pathophysiologic Basis of Connected Health Systems.

Pathophysiologic Basis of Connected Health Systems.

Publication date: Sep 21, 2023

Since the start of the COVID-19 pandemic, there has been a rapid transition to telehealth across the United States, primarily involving virtual clinic visits. Additionally, the proliferation of consumer technologies related to health reveals that for many people health and care in the contemporary world extends beyond the boundaries of a clinical interaction and includes sensors and devices that facilitate health in personal environments. The ideal connected environment is networked and intelligent, personalized to promote health and prevent disease. The combination of sensors, devices, and intelligence constitutes a connected health system around an individual that is optimized to improve and maintain health, deliver care, and predict and reduce risk of illness. Just as modern medicine uses the pathophysiology of disease as a framework for the basis of pharmacologic therapy, a similar clinically reasoned approach can be taken to organize and architect technological elements into therapeutic systems. In this work, we introduce a systematic methodology for the design of connected health systems grounded in the pathophysiologic basis of disease. As the digital landscape expands with the ubiquity of health devices, it is pivotal to enable technology-agnostic clinical reasoning to guide the integration of technological innovations into systems of health and care delivery that extend beyond the boundaries of a clinical interaction. Applying clinical reasoning in a repeatable and systematic way to organizing technology into therapeutic systems can yield potential benefits including expanding the study of digital therapeutics from individual devices to networked technologies as therapeutic interventions; empowering physicians who are not technological experts to still play a significant role in using clinical reasoning for architecting therapeutic networks of sensors and devices; and developing platforms to catalog and share combinations of technologies that can form therapeutic networks and connected health systems.

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Concepts Keywords
Agnostic clinic
Architecting community
Clinic connected health
Covid design
Expanding digital therapeutic
smart health
systematic methodology
therapeutic systems


Type Source Name
disease MESH COVID-19 pandemic
drug DRUGBANK Methylphenidate
disease MESH Crohn disease
disease MESH ADHD
disease MESH autism
disease MESH anxiety disorders
disease IDO intervention
disease IDO process
disease MESH complications
disease VO time
disease VO population
disease IDO history
disease MESH obesity
drug DRUGBANK Metformin
drug DRUGBANK Glipizide
disease MESH hypertension
disease MESH stroke
disease MESH arthritis
disease VO monthly
disease VO company
disease MESH sleep quality
disease MESH nocturia
drug DRUGBANK Nonoxynol-9
disease IDO blood
drug DRUGBANK Dextrose unspecified form
disease VO dose
drug DRUGBANK Acetylsalicylic acid
disease MESH cardiovascular disease
disease MESH lifestyle
disease MESH posture
disease MESH sleep apnea
disease MESH neuropathic pain
disease VO syringe
disease IDO algorithm
disease MESH hypoglycemia
disease VO device
disease VO volume
drug DRUGBANK Etoperidone
drug DRUGBANK Aspartame
disease MESH ulcerative colitis
disease MESH asthma
pathway KEGG Asthma
disease MESH Allergy
disease MESH chronic diseases
disease MESH inflammation
disease MESH Paroxysmal nocturnal hemoglobinuria
disease MESH stable angina pectoris
disease MESH Heart failure
disease MESH diabetes mellitus
disease MESH Coronavirus infections
drug DRUGBANK Guanosine
pathway REACTOME Reproduction

Original Article

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