Publication date: Sep 22, 2023
We herein report a case of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) that occurred following coronavirus disease 2019 (COVID-19) vaccination and its subsequent relapse after COVID-19 infection. A 34-year-old woman developed cortical encephalitis in the right temporoparietal lobe one week after receiving the mRNA-1273 vaccine. The cerebrospinal fluid was positive for anti-MOG antibody. Her symptoms gradually improved after three courses of intravenous methylprednisolone therapy. Six months later, she experienced a relapse of transverse myelitis following COVID-19 infection. Despite treatment with plasma exchange, the patient remained paralyzed in both lower limbs. We herein review the relationship between MOGAD and COVID-19 vaccination/infection.
| Concepts | Keywords |
|---|---|
| Coronavirus | Anti MOG antibody |
| Methylprednisolone | Cortical encephalitis |
| Old | COVID-19 infection |
| Therapy | COVID-19 vaccination |
| Transverse myelitis |
Semantics
| Type | Source | Name |
|---|---|---|
| disease | VO | Glycoprotein |
| disease | MESH | associated Disease |
| disease | MESH | Coronavirus Disease 2019 |
| disease | VO | vaccination |
| disease | MESH | Infection |
| disease | VO | report |
| disease | MESH | Encephalitis |
| disease | MESH | Transverse Myelitis |
| disease | VO | vaccine |
| drug | DRUGBANK | Methylprednisolone |