Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity.

Publication date: Nov 27, 2023

The COVID-19 pandemic has revealed the lack of effective treatments against betacoronaviruses and the urgent need for new broad-spectrum antivirals. Natural products are a valuable source of bioactive compounds with pharmaceutical potential that may lead to the discovery of new antiviral agents. Specifically, compared to conventional synthetic molecules, microbial natural extracts possess a unique and vast chemical diversity and are amenable to large-scale production. The implementation of a high-throughput screening platform using the betacoronavirus OC43 in a human cell line infection model has provided proof of concept of the approach and has allowed for the rapid and efficient evaluation of 1,280 microbial extracts. The identification of several active compounds validates the potential of the platform for the search for new compounds with antiviral capacity.

Concepts Keywords
Betacoronaviruses antivirals
Efficient coronavirus
Microbiol HCoV-OC43
Pandemic high-content screening
microbial extracts
natural products


Type Source Name
disease MESH COVID-19 pandemic
disease VO LACK
disease VO effective
disease IDO production
disease VO Betacoronavirus
disease IDO cell
disease MESH infection
disease VO efficient

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