Exploring the Association between Delirium and Malnutrition in COVID-19 Survivors: A Geriatric Perspective.

Publication date: Nov 09, 2023

Older individuals face an elevated risk of developing geriatric syndromes when confronted with acute stressors like COVID-19. We assessed the connection between in-hospital delirium, malnutrition, and frailty in a cohort of COVID-19 survivors. Patients aged ≥65, hospitalized in a tertiary hospital in Milan for SARS-CoV-2 pneumonia, were enrolled and screened for in-hospital delirium with the 4 ‘A’s Test (4AT) performed twice daily (morning and evening) during hospital stay. Malnutrition was assessed with the malnutrition universal screening tool (MUST) at hospital admission and with the mini-nutritional assessment short-form (MNA-SF) one month after hospital discharge. Frailty was computed with the frailty index one month after hospital discharge. Fifty patients (median age 78. 5, 56% male) were enrolled. At hospital admission, 10% were malnourished. The 13 patients (26%) who developed delirium were frailer (7 vs. 4), experienced a higher in-hospital mortality (5 vs. 3), and were more malnourished one month after discharge (3 of the 4 patients with delirium vs. 6 of the 28 patients without delirium who presented at follow up). The 4AT scores correlated with the MNA-SF scores (r = -0. 55, p = 0. 006) and frailty (r = 0. 35, p = 0. 001). Frailty also correlated with MUST (r = 0. 3, p = 0. 04), MNA-SF (r = -0. 42, p = 0. 02), and hospitalization length (r = 0. 44, p = 0. 001). Delirium, malnutrition, and frailty are correlated in COVID-19 survivors. Screening for these geriatric syndromes should be incorporated in routine clinical practice.

Open Access PDF

Concepts Keywords
Daily Aged
Hospitalization COVID-19
Malnutrition COVID-19 survivors
Milan Delirium
Pneumonia delirium
Geriatric Assessment
geriatric syndromes
Nutrition Assessment
Nutritional Status
Prospective Studies


Type Source Name
disease MESH Delirium
disease MESH Malnutrition
disease MESH COVID-19
disease MESH syndromes
disease MESH pneumonia
disease MESH Liver Disease
disease MESH Infectious Diseases
disease MESH chronic conditions
drug DRUGBANK Coenzyme M
disease MESH dysphagia
disease VO oral route
disease MESH respiratory diseases
drug DRUGBANK Oxygen
disease MESH morbidity
disease MESH weight loss
disease VO protocol
disease MESH emergency
disease MESH nutritional status
disease MESH sarcopenia
disease MESH muscle strength
disease VO population
disease VO USA
disease VO vaccine
disease VO vaccination
drug DRUGBANK Heparin
disease MESH tumors
disease MESH Hypertension
disease MESH Dyslipidemia
disease MESH Atrial fibrillation
disease MESH Heart failure
disease MESH pulmonary embolism
disease MESH deep venous thrombosis
disease MESH Stroke
disease MESH Arthrosis
disease MESH Anemia
disease IDO blood
drug DRUGBANK Urea
drug DRUGBANK Creatinine
disease MESH Death
drug DRUGBANK Pentaerythritol tetranitrate

Original Article

(Visited 1 times, 1 visits today)