Torquetenovirus Loads in Peripheral Blood Predict Both the Humoral and Cell-Mediated Responses to SARS-CoV-2 Elicited by the mRNA Vaccine in Liver Transplant Recipients.

Publication date: Oct 28, 2023

Three years into the COVID-19 pandemic, mass vaccination campaigns have largely controlled the disease burden but have not prevented virus circulation. Unfortunately, many immunocompromised patients have failed to mount protective immune responses after repeated vaccinations, and liver transplant recipients are no exception. Across different solid organ transplant populations, the plasma levels of Torquetenovirus (TTV), an orphan and ubiquitous human virus under control of the immune system, have been shown to predict the antibody response after COVID-19 vaccinations. We show here a single-institution experience with TTV viremia in 134 liver transplant recipients at their first or third dose. We found that TTV viremia before the first and third vaccine doses predicts serum anti-SARS-CoV-2 Spike receptor-binding domain (RBD) IgG levels measured 2-4 weeks after the second or third dose. Pre-vaccine TTV loads were also associated with peripheral blood anti-SARS-CoV-2 cell-mediated immunity but not with serum SARS-CoV-2 neutralizing antibody titers.

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Concepts Keywords
Immunocompromised anti-spike antibodies
Liver COVID-19
Mrna liver transplantation
Organ neutralizing antibodies
Weeks TTV
vaccination

Semantics

Type Source Name
disease IDO blood
disease IDO cell
disease VO vaccine
disease MESH COVID-19 pandemic
disease VO vaccination
disease MESH immunocompromised patients
pathway REACTOME Immune System
disease MESH viremia
disease VO dose
disease MESH Infectious Diseases
drug DRUGBANK Coenzyme M
disease IDO immunosuppression
disease MESH infections
disease MESH morbidity
disease VO population
disease VO Viruses
disease IDO replication
disease MESH persistent infections
disease IDO host
disease IDO infection
disease VO vaccine dose
drug DRUGBANK Cefalotin
disease VO gene
disease IDO assay

Original Article

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