Endothelial biomarkers in critically-ill COVID-19 patients: potential predictors of the need for dialysis.

Publication date: Nov 28, 2023

To evaluate the function of vascular biomarkers to predict need for hemodialysis in critically-ill patients with COVID-19. This is a prospective study with 58 critically-ill patients due to COVID-19 infection. Laboratory tests in general and vascular biomarkers, such as VCAM-1, Syndecan-1, Angiopoietin-1 and Angiopoeitin-2 were quantified on intensive care unit (ICU) admission. There was a 40% death rate. VCAM and Ang-2/Ang-1 ratio on ICU admission were associated with need for hemodialysis. Vascular biomarkers (VCAM-1, Syndecan-1, angiopoetin-2/ anogiopoetin-1 ratio) were predictors of death and their cut-off values were useful to stratify patients with a worse prognosis. In the multivariate cox regression analysis with adjusted models, VCAM-1 [O. R. 1. 13 (C. I. 95%: 1. 01 – 1. 27); p= 0. 034] and Ang-2/Ang-1 ratio [O. R. 4. 87 (C. I.95%: 1. 732 – 13. 719); p= 0. 003] were associated with need for dialysis. Vascular biomarkers, mostly VCAM-1 and Ang-2/Ang-1 ratio, showed better efficiency to predict need for hemodialysis in critically-ill COVID-19 patients.

Concepts Keywords
Hemodialysis Admission
Laboratory Ang
Models Biomarkers
Worse Covid
Dialysis
Hemodialysis
Icu
Ill
Patients
Predict
Predictors
Ratio
Syndecan
Vascular
Vcam

Semantics

Type Source Name
disease MESH COVID-19
disease MESH infection
disease MESH death
drug DRUGBANK Tropicamide
disease VO efficiency

Original Article

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