Biochemical Alterations Associated With the Severity of COVID-19 in Sub-Saharan Black African Individuals.

Publication date: Nov 29, 2023

Biochemical markers are essential in the monitoring and the clinical care of patients as they inform clinicians. Here, we characterized biochemical alterations in sub-Saharan Black African individuals with COVID-19. The study includes COVID-19 patients cared for at the Akanda Army Hospital in Libreville (Gabon). A total of 2237 patient records were extracted and reviewed. Patients were classified based on hospital admission (intensive care unit [ICU], internal medicine ward, and outpatient). One thousand six hundred seventy-one were included in the study. ICU patients were significantly older than non-ICU hospitalized patients (P < 0. 001) and outpatients (P < 0. 0001). Hyperglycemic patients had 6. 4 odds of being in ICU (P < 0. 0001). Patients with abnormally high urea had 54. 7 odds of being in ICU (P < 0. 0001). Patients with abnormally high aspartate aminotransferase (AST) (>33 IU/L) had 3. 5 odds of being in ICU (P < 0. 0001). Hyperlactatemia (>246 IU/L) odds in ICU patients were 14 (P < 0. 0001). The odds of abnormally high alkaline phosphatase (ALP) (>147 IU/L) in ICU patients were 4. 6 (P < 0. 0001). Odds for hypochloremia (

Concepts Keywords
Biochemical African
Black Alterations
Gabon Biochemical
Outpatients Black
Seventy Care


Type Source Name
disease MESH COVID-19
drug DRUGBANK Urea
disease MESH Hyperlactatemia
drug DRUGBANK Alkaline Phosphatase

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