COVID-19 vaccination acceptance, safety and side-effects in European patients with severe asthma.

Publication date: Nov 01, 2023

Vaccination is vital for achieving population immunity to severe acute respiratory syndrome coronavirus 2, but vaccination hesitancy presents a threat to achieving widespread immunity. Vaccine acceptance in chronic potentially immunosuppressed patients is largely unclear, especially in patients with asthma. The aim of this study was to investigate the vaccination experience in people with severe asthma. Questionnaires about vaccination beliefs (including the Vaccination Attitudes Examination (VAX) scale, a measure of vaccination hesitancy-related beliefs), vaccination side-effects, asthma control and overall safety perceptions following coronavirus disease 2019 (COVID-19) vaccination were sent to patients with severe asthma in 12 European countries between May and June 2021. 660 participants returned completed questionnaires (87. 4% response rate). Of these, 88% stated that they had been, or intended to be, vaccinated, 9. 5% were undecided/hesitant and 3% had refused vaccination. Patients who hesitated or refused vaccination had more negative beliefs towards vaccination. Most patients reported mild (48. 2%) or no side-effects (43. 8%). Patients reporting severe side-effects (5. 7%) had more negative beliefs. Most patients (88. 8%) reported no change in asthma symptoms after vaccination, while 2. 4% reported an improvement, 5. 3% a slight deterioration and 1. 2% a considerable deterioration. Almost all vaccinated (98%) patients would recommend vaccination to other severe asthma patients. Uptake of vaccination in patients with severe asthma in Europe was high, with a small minority refusing vaccination. Beliefs predicted vaccination behaviour and side-effects. Vaccination had little impact on asthma control. Our findings in people with severe asthma support the broad message that COVID-19 vaccination is safe and well tolerated.

Open Access PDF

Concepts Keywords
Coronavirus Acceptance
Europe Achieving
June Asthma
Safe Beliefs
Vaccinated Coronavirus


Type Source Name
disease MESH COVID-19
disease VO vaccination
disease MESH asthma
pathway KEGG Asthma
disease VO population
disease VO Severe acute respiratory syndrome coronavirus 2
disease VO vaccine
disease VO vaccinated

Original Article

(Visited 1 times, 1 visits today)