Purinergic signaling in the battlefield of viral infections.

Publication date: Dec 01, 2023

Purinergic signaling has been associated with immune defenses against pathogens such as bacteria, protozoa, fungi, and viruses, acting as a sentinel system that signals to the cells when a threat is present. This review focuses on the roles of purinergic signaling and its therapeutic potential for viral infections. In this context, the purinergic system may play potent antiviral roles by boosting interferon signaling. In other cases, though, it can contribute to a hyperinflammatory response and disease severity, resulting in poor outcomes, such as during flu and potentially COVID-19. Lastly, a third situation may occur since viruses are obligatory intracellular parasites that hijack the host cell machinery for their infection and replication. Viruses such as HIV-1 use the purinergic system to favor their infection and persistence within the host cell. Therefore, understanding the particular nuances of purinergic signaling in each viral infection may contribute to designing proper therapeutic strategies to treat viral diseases.

Concepts Keywords
Battlefield Hyperinflammation
Fungi Innate antiviral immune
Protozoa Purinergic signaling
Therapeutic Viral infection


Type Source Name
disease MESH viral infections
disease VO Bacteria
disease VO Protozoa
disease VO Fungi
disease VO Viruses
pathway REACTOME Interferon Signaling
disease MESH COVID-19
disease MESH infection
disease IDO replication

Original Article

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