Association between fat-free mass and survival in critically ill patients with COVID-19: a prospective cohort study.

Publication date: Nov 30, 2023

Most critically ill patients with COVID-19 suffer from malnutrition and weight loss associated with negative clinical outcomes. Our primary aim was to assess body composition during acute and late phase of illness in these patients in relation to clinical outcome and secondary to tailored nutritional support. Prospective cohort study including adult critically ill COVID-19 patients. Body composition (fat-free mass (FFM) (exposure of interest), fat mass (FM), skeletal muscle mass (SMM), phase angle (PA)) was determined with multifrequency bio-electrical impedance analyses (BIA) in the acute and late phase. Nutritional support data were collected simultaneously. Clinical outcome was defined as ICU survival (primary outcome) and 30-90 days thereafter, duration of mechanical ventilation, length of ICU stay and hospital stay (LOS). Non-parametric tests and regression analyses were performed. We included 70 patients (73% male, median age 60 years). Upon admission median BMI was 30kg/m : 54% obese (BMI>30kg/m ). Median weight change during ICU stay was -3kg: +3kg FM and -6kg FFM (-4kg SMM). Body composition changed significantly (p80%) during acute phase maintained significantly more FFM (2. 7kg,p=0. 047) and SMI (0. 5 kg/m2,p=0. 049) in the late phase compared with patients who received

Concepts Keywords
7kgp Body composition
Hospital Clinical Outcome
Malnutrition COVID-19
Parenter Critically ill patients
Nutritional assessment


Type Source Name
disease MESH critically ill
disease MESH COVID-19
disease MESH malnutrition
disease MESH weight loss

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