Cardiac manifestations of MIS-C: cardiac magnetic resonance and speckle-tracking data.

Publication date: Sep 03, 2023

Cardiac involvement is central in MIS-C and represents the main cause of morbidity. In this study, we aimed to assess myocardial damage in patients with MIS-C using cardiac magnetic resonance (CMR) during the acute phase, as well as left ventricular and atrial longitudinal strain on admission, at discharge, and after 3 months. We performed a single-center prospective cohort study and case-control study. Between September 2020 and February 2022, we enrolled 39 patients hospitalized for MIS-C at our center. We performed left ventricular and atrial longitudinal 2D strain analysis on admission and during follow-up; echocardiographic data were compared to a matched control population. Patients above 4 years old with increased troponin underwent CMR. Of 24 patients (mean age: 8. 2ā€‰+/-ā€‰4. 9 years) who underwent CMR, 14 (58%) presented myocardial edema and 6 (25%) late gadolinium enhancement (LGE). LGE was associated with older age (pā€‰

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Concepts Keywords
Atrial cardiac injury
Cardiovasc cardiac magnetic resonance
February COVID-19
September myocarditis
speckle-tracking imaging


Type Source Name
disease MESH morbidity
disease VO population
disease MESH edema
drug DRUGBANK Gadolinium
pathway REACTOME Reproduction
disease VO time
disease MESH global longitudinal strain
disease MESH COVID 19
disease MESH syndrome
disease MESH myocarditis
drug DRUGBANK Nesiritide
disease MESH multisystem inflammatory syndrome in children

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