Enhanced neutralization of SARS-CoV-2 variant BA.2.86 and XBB sub-lineages by a tetravalent COVID-19 vaccine booster.

Publication date: Nov 22, 2023

Emerging SARS-CoV-2 sub-lineages like XBB. 1.5, XBB. 1.16, EG. 5, HK. 3 (FLip), and XBB. 2.3 and the variant BA. 2.86 have recently been identified. Understanding the efficacy of current vaccines on these emerging variants is critical. We evaluate the serum neutralization activities of participants who received COVID-19 inactivated vaccine (CoronaVac), those who received the recently approved tetravalent protein vaccine (SCTV01E), or those who had contracted a breakthrough infection with BA. 5/BF. 7/XBB virus. Neutralization profiles against a broad panel of 30 sub-lineages reveal that BQ. 1.1, CH. 1.1, and all the XBB sub-lineages exhibit heightened resistance to neutralization compared to previous variants. However, despite their extra mutations, BA. 2.86 and the emerging XBB sub-lineages do not demonstrate significantly increased resistance to neutralization over XBB. 1.5. Encouragingly, the SCTV01E booster consistently induces higher neutralizing titers against all these variants than breakthrough infection does. Cellular immunity assays also show that the SCTV01E booster elicits a higher frequency of virus-specific memory B cells. Our findings support the development of multivalent vaccines to combat future variants.

Concepts Keywords
Future Ba
Host Booster
Inactivated Cov
Sctv01e Emerging
Vaccine Lineages


Type Source Name
disease VO COVID-19 vaccine
disease VO COVID-19 inactivated vaccine
disease VO CoronaVac
disease VO vaccine
disease MESH breakthrough infection
disease VO frequency

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