Use of non-invasive transcutaneous auricular vagus nerve stimulation: neurodevelopmental and sensory follow-up.

Publication date: Sep 19, 2023

To assess the impact of non-invasive transcutaneous auricular vagal nerve stimulation (taVNS) paired with oral feeding on long-term neurodevelopmental and sensory outcomes. We tested 21 of 35 children who as infants were gastrostomy tube (G-tube) candidates and participated in the novel, open-label trial of taVNS paired with oral feeding. To evaluate possible effects on development at 18-months after infant taVNS, we performed the Bayley-III (nā€‰=ā€‰10) and Sensory Profile (SP-2, nā€‰=ā€‰12) assessments before the COVID pandemic, and Cognitive Adaptive Test (CAT), Clinical Linguistics and Auditory Milestone (CLAMS), Ages and Stages Questionnaire (ASQ), and Peabody Developmental Motor Scales-2 gross motor tests as possible during and after the pandemic. We compared outcomes for infants who attained full oral feeds during taVNS (‘responders’) or received G-tubes (‘non-responders’). At a mean of 19-months, taVNS ‘responders’ showed significantly better general sensory processing on the SP-2 than ‘non-responders’. There were no differences in other test scores, which were similar to published outcomes for infants who required G-tubes. This is the first report of neurodevelopmental follow-up in infants who received taVNS-paired feeding. They had similar developmental outcomes as historical control infants failing oral feeds who received G-tubes. Our data suggests that infants who attained full oral feeds had better sensory processing.

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Concepts Keywords
Cat feeding delay
Clams infants
Months neurodevelopmental delay
Neurodevelopmental sensory processing
Novel taVNS

Semantics

Type Source Name
drug DRUGBANK Tropicamide
disease VO report
pathway REACTOME Reproduction
disease IDO intervention
disease MESH stroke
drug DRUGBANK Acetylcholine
drug DRUGBANK Norepinephrine
drug DRUGBANK Etoperidone
disease VO device
disease VO protocol
disease MESH Autism
disease MESH abnormalities
disease IDO history
disease MESH Hypoxic ischemic encephalopathy
disease MESH Periventricular leukomalacia
disease MESH Sepsis
disease MESH Necrotizing enterocolitis
disease MESH pulmonary hypertension
disease MESH Patent ductus arteriosus
disease MESH atrophy
disease MESH gliosis

Original Article

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