Omicron BA.2 breakthrough infection elicits CD8 T cell responses recognizing the spike of later Omicron subvariants.

Omicron BA.2 breakthrough infection elicits CD8 T cell responses recognizing the spike of later Omicron subvariants.

Publication date: Jan 19, 2024

Here, we examine peripheral blood memory T cell responses against the SARS-CoV-2 BA. 4/BA. 5 variant spike among vaccinated individuals with or without Omicron breakthrough infections. We provide evidence supporting a lack of original antigenic sin in CD8 T cell responses targeting the spike. We show that BNT162b2-induced memory T cells respond to the BA. 4/BA. 5 spike. Among individuals with BA. 1/BA. 2 breakthrough infections, IFN-γ-producing CD8 T cell responses against the BA. 4/BA. 5 spike increased. In a subgroup with BA. 2 breakthrough infections, IFN-γ-producing CD8 T cell responses against the BA. 2-mutated spike region increased and correlated directly with responses against the BA. 4/BA. 5 spike, indicating that BA. 2 spike-specific CD8 T cells elicited by BA. 2 breakthrough infection cross-react with the BA. 4/BA. 5 spike. We identified CD8 T cell epitope peptides that are present in the spike of BA. 2 and BA. 4/BA. 5 but not the original spike. These peptides are fully conserved in the spike of now-dominant XBB lineages. Our study shows that breakthrough infection by early Omicron subvariants elicits CD8 T cell responses that recognize epitopes within the spike of newly emerging subvariants.

Concepts Keywords
Bnt162b2 Ba
Breakthrough Breakthrough
Cd8 Cd8
Infections Elicits
Vaccinated Ifn
Increased
Individuals
Infection
Infections
Memory
Omicron
Original
Producing
Spike
Subvariants

Semantics

Type Source Name
disease MESH breakthrough infection
disease IDO cell
disease IDO blood
disease VO vaccinated
disease VO LACK

Original Article

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