Altered IgG4 Antibody Response to Repeated mRNA versus Protein COVID Vaccines

Publication date: Jan 17, 2024

Repeated mRNA SARS-CoV-2 vaccination has been associated with increases in the proportion of IgG4 in spike-specific antibody responses and concurrent reductions in Fc{gamma}-mediated effector functions that may limit control of viral infection. Here, we assessed anti-Spike total IgG, IgG1, IgG2, IgG3 and IgG4, and surrogate markers for antibody-dependent cellular phagocytosis (ADCP, Fc{gamma}RIIa binding), antibody-dependent cellular cytotoxicity (ADCC, Fc{gamma}RIIIa binding), and antibody-dependent complement deposition (ADCD, C1q binding) associated with repeated SARS-CoV-2 vaccination with NVX-CoV2373 (Novavax Inc., Gaithersburg, MD). The NVX-CoV2373 protein vaccine did not induce notable increases in spike-specific IgG4 or negatively impact surrogates for Fc{gamma} effector responses. Conversely, repeated NVX-CoV2373 vaccination uniquely enhanced IgG3 responses which are known to exhibit strong affinity for Fc{gamma}RIIIa and have previously been linked to potent neutralization of SARS-CoV-2. Subsequent investigations will help to understand the immunological diversity generated by different SARS-CoV-2 vaccine types and have the potential to reshape public health strategies.

Concepts Keywords
Cat Antibody
Goldblat Cov
Pools Cov2373
Spd Doi
Vaccines11050991 Igg


Type Source Name
disease VO vaccination
disease MESH viral infection
disease VO NVX-CoV2373
disease VO vaccine
drug DRUGBANK Carboxyamidotriazole
disease VO USA
drug DRUGBANK Coenzyme M
disease MESH Infection
disease MESH COVID 19
disease VO dose
disease IDO immunosuppression
disease VO vaccine dose
disease IDO assay
disease IDO cell
disease MESH clinical importance
drug DRUGBANK Spinosad
disease MESH Allergy
disease MESH Infectious Diseases
disease MESH AIDS
disease MESH Immune Tolerance
disease VO titer

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