New-Onset Psoriatic Arthritis Following COVID-19 mRNA Vaccination in a Psoriatic Patient Under Anti-tumor Necrosis Factor Alpha Biologic Treatment: What Now?

New-Onset Psoriatic Arthritis Following COVID-19 mRNA Vaccination in a Psoriatic Patient Under Anti-tumor Necrosis Factor Alpha Biologic Treatment: What Now?

Publication date: Dec 01, 2023

During the COVID-19 pandemic, anti-SARS-CoV-2 vaccines were quickly developed and administered to the population worldwide. As is expected with new vaccine products, adverse reactions following immunization have been reported, namely, the development and/or exacerbation of autoimmune/autoinflammatory diseases, including rheumatic diseases. Here, we report a clinical case of a 56-year-old woman with a 44-year history of moderate-to-severe plaque psoriasis under treatment with an anti-tumor necrosis factor alpha biosimilar (adalimumab) with good control of skin disease and without rheumatic involvement to date who came to us with complaints of migratory polyarthralgia starting one week after receiving the second dose of the BNT162b2 COVID-19 mRNA vaccine. The condition progressed over the following months and a diagnosis of psoriatic arthritis was established. Biologic treatment was switched to an anti-interleukin 17A (secukinumab), with a very good clinical cutaneous and articular response, which was sustained up to the present moment. The mechanisms behind the exacerbation or new-onset of autoimmune/autoinflammatory diseases after receiving anti-COVID-19 vaccines are not yet fully understood, requiring further investigation. It is also not known whether rheumatic symptoms post-COVID-19 infection will have similar mechanisms to rheumatic symptoms post-anti-COVID-19 vaccination. With the continuing worldwide vaccination against SARS-CoV-2, clinicians need to be prepared to discuss the risks and benefits of vaccination and should be aware that it may cause or exacerbate immune disorders such as psoriatic arthritis, warranting close follow-up in terms of disease progression and treatment.

Concepts Keywords
Bnt162b2 autoimmune disease flare
Clinicians biologic treatment
New covid-19 vaccination
Old mrna vaccine
Vaccines psoriasis
psoriatic arthritis
reactive arthritis

Semantics

Type Source Name
disease MESH Psoriatic Arthritis
disease MESH COVID-19
disease VO vaccination
disease VO population
disease VO vaccine
disease VO immunization
disease MESH rheumatic diseases
disease VO report
disease IDO history
disease MESH psoriasis
drug DRUGBANK Adalimumab
disease MESH skin disease
disease MESH polyarthralgia
disease VO dose
drug DRUGBANK Secukinumab
disease MESH infection
disease MESH immune disorders
disease MESH disease progression
disease MESH autoimmune disease
disease MESH reactive arthritis

Original Article

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