Association of ABO blood group, Rh phenotype and MN blood group with susceptibility to COVID-19.

Association of ABO blood group, Rh phenotype and MN blood group with susceptibility to COVID-19.

Publication date: Jan 19, 2024

Previous studies have reported that the susceptibility to coronavirus disease 2019 (COVID-19) is related to ABO blood group, but the relationship with Rh phenotype and MN blood group is unknown. China had adopted a strict control policy on COVID-19 until December 5, 2022, when local communities were liberalized. Therefore, we aimed to explore the correlation between ABO blood group, Rh phenotype, MN blood group and susceptibility to COVID-19 based on the time sequence of infection during the pandemic. A total of 870 patients who were routinely hospitalized in Ningbo Medical Center Lihuili Hospital from March 1, 2023 to March 31, 2023 were randomly selected to enroll in this study. Patients were divided into susceptible group and non-susceptible group, according to the time of their previous infection. The demographics and clinical information of the enrolled participants were collected from electronic medical records. The association of ABO blood group, Rh phenotype and MN blood group with susceptibility to COVID-19 was analyzed. A total of 650 cases (74. 7%) had been infected with COVID-19, with 157 cases (18. 0%) in the second week and 252 cases (29. 0%) in the third week, reaching the peak of infection. Compared with the non-susceptible group, the susceptible group had no statistically significant differences in ABO blood group and Rh phenotype, but the proportion of N+ was higher (75. 6% vs 68. 9%, P = 0. 030) and the proportion of MM was lower (24. 4% vs 31. 1%, P = 0. 030). Consistent with this, ABO blood group and Rh phenotype were not significantly associated with susceptibility to COVID-19 (P>0. 05), while N+ and MM were associated with susceptibility to COVID-19 (OR: 1. 432, 95% confidence interval [CI]: 1. 049, 1. 954, P = 0. 024; OR: 0. 698, 95% CI: 0. 512, 0. 953, P = 0. 024, respectively), after adjusting for age, sex, BMI, basic disease, and vaccination status in multivariate logistic regression analysis. Our study showed that ABO blood group and Rh phenotype may not be related to the susceptibility to COVID-19, but MN blood group may be associated with the susceptibility to COVID-19.

Open Access PDF

Concepts Keywords
China Abo
Coronavirus Blood
December Clinical
Liberalized Covid
Group
Infection
March
Phenotype
Previous
Proportion
Related
Susceptibility
Susceptible
Total
Week

Semantics

Type Source Name
disease IDO blood
disease IDO susceptibility
disease MESH COVID-19
disease VO time
disease MESH infection
disease VO vaccination
disease MESH Long Covid
drug DRUGBANK Coenzyme M
pathway REACTOME Reproduction
disease MESH pneumonia
disease VO organization
disease MESH allergies
disease MESH asthma
pathway KEGG Asthma
drug DRUGBANK Angiotensin II
disease MESH infectious diseases
drug DRUGBANK L-Phenylalanine
drug DRUGBANK Pentaerythritol tetranitrate
disease MESH malignancy
disease MESH hypertension
disease VO effective
disease IDO country
disease VO USA

Original Article

(Visited 1 times, 1 visits today)