Causal relationship between COVID-19 and chronic pain: A mendelian randomization study.

Causal relationship between COVID-19 and chronic pain: A mendelian randomization study.

Publication date: Jan 19, 2024

COVID-19 is a highly transmissible disease that can result in long-term symptoms, including chronic pain. However, the mechanisms behind the persistence of long-COVID pain are not yet fully elucidated, highlighting the need for further research to establish causality. Mendelian randomization (MR), a statistical technique for determining a causal relationship between exposure and outcome, has been employed in this study to investigate the association between COVID-19 and chronic pain. The IVW, MR Egger, and weighted median methods were employed. Heterogeneity was evaluated using Cochran’s Q statistic. MR Egger intercept and MR-PRESSO tests were performed to detect pleiotropy. The Bonferroni method was employed for the correction of multiple testing. R software was used for all statistical analyses. Based on the IVW method, hospitalized COVID-19 patients exhibit a higher risk of experiencing lower leg joint pain compared to the normal population. Meanwhile, the associations between COVID-19 hospitalization and back pain, headache, and pain all over the body were suggestive. Additionally, COVID-19 patients requiring hospitalization were found to have a suggestive higher risk of experiencing neck or shoulder pain and pain all over the body compared to those who did not require hospitalization. Patients with severe respiratory-confirmed COVID-19 showed a suggestive increased risk of experiencing pain all over the body compared to the normal population. Our study highlights the link between COVID-19 severity and pain in different body regions, with implications for targeted interventions to reduce COVID-19 induced chronic pain burden.

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Concepts Keywords
Covid Body
Headache Causal
Hospitalization Chronic
Increased Compared


Type Source Name
disease MESH COVID-19
disease MESH chronic pain
disease MESH causality
disease MESH joint pain
disease VO population
disease MESH back pain
disease MESH Long Covid
disease MESH Cancer
drug DRUGBANK Coenzyme M
disease IDO history
disease IDO process
pathway REACTOME Reproduction
disease VO mouth
disease MESH heart disease
disease MESH obesity
disease MESH complications
disease MESH infection
disease MESH inflammation
disease MESH emotional stress
disease IDO quality
disease IDO intervention
disease MESH Low back pain
disease VO stomach
disease VO frequency
drug DRUGBANK Trestolone
disease IDO symptom
disease MESH syndrome
disease MESH migraine
disease MESH arthritis
disease IDO acute infection
disease VO organ
disease MESH cytokine storm
disease IDO site
drug DRUGBANK Angiotensin II
disease MESH osteoarthritis
disease MESH genetic markers
drug DRUGBANK Ranitidine
disease MESH lifestyle
disease VO effective
drug DRUGBANK (S)-Des-Me-Ampa
drug DRUGBANK Guanosine
drug DRUGBANK L-Asparagine
disease MESH metabolic diseases
disease MESH chronic fatigue syndromes
disease MESH musculoskeletal pain
disease MESH Reactive arthritis
disease MESH neuropathic pain

Original Article

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