Anti-SARS-CoV-2 IgG antibody after the second and third mRNA vaccinations in staff and residents in a nursing home with a previous COVID-19 outbreak in Niigata, Japan.

Anti-SARS-CoV-2 IgG antibody after the second and third mRNA vaccinations in staff and residents in a nursing home with a previous COVID-19 outbreak in Niigata, Japan.

Publication date: Feb 01, 2024

This study measured IgG antibody titers against spike (S) and nucleocapsid (N) proteins of SARS-CoV-2 before vaccination and after the second and third doses of an mRNA vaccine in staff and residents of a nursing home in Niigata, Japan. The study included 52 staff members, of whom six (11. 5%) were previously infected with SARS-CoV-2, and 32 older residents, of whom 22 (68. 8%) were previously infected. All participants received the first two doses in April-July 2021 and a third dose in January-March 2022. In staff, the median anti-S antibody titers (interquartile range) in previously infected and SARS-CoV-2-nacEFve individuals before vaccination were 960 (592-1,926) and 0. 5 (0. 0-2. 1) arbitrary units (AU)/mL. Anti-S antibody titers 5 months after the second and third doses in previously infected staff were 7,391 (5,230-7,747) and 10,195 (5,582-13,886) AU. In residents, the median anti-S antibody titers in previously infected and nacEFve individuals before vaccination were 734 (425-1,934) and 1. 1 (0. 0-3. 1) AU/mL. Anti-S antibody titers at 5 months after the second and third doses in previously infected residents were 15,872 (9,683-21,557) and 13,813 (6,689-20,839) AU/mL; however, there were no significant differences in titers between the second and third doses in previously infected residents. Anti-N antibody titers were higher in previously infected than nacEFve individuals, and titers decreased chronologically.

Concepts Keywords
Japan Antibody response
July Hybrid immunity
Vaccinations Nursing home
Previous infection
SARS-CoV-2
Vaccination

Semantics

Type Source Name
drug DRUGBANK Etoperidone
disease MESH COVID-19
disease VO vaccination
disease VO vaccine
disease VO dose
disease MESH infection

Original Article

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