Mental health outcomes of endometriosis patients during the COVID-19 pandemic: Impact of pre-pandemic central nervous system sensitization.

Mental health outcomes of endometriosis patients during the COVID-19 pandemic: Impact of pre-pandemic central nervous system sensitization.

Publication date: Jan 19, 2024

To correlate pain-related phenotyping for central nervous system sensitization in endometriosis-associated pain with mental health outcomes during the COVID-19 pandemic, the prospective Endometriosis and Pelvic Pain Interdisciplinary Cohort (EPPIC, ClinicalTrials. gov #NCT02911090) was linked to the COVID-19 Rapid Evidence Study of a Provincial Population Based Cohort for Gender and Sex (RESPPONSE) dataset. The primary outcomes were depression (PHQ-9) and anxiety (GAD-7) scores during the pandemic. The explanatory variables of interest were the Central Sensitization Inventory (CSI) score (0-100) and endometriosis-associated chronic pain comorbidities/psychological variables before the pandemic. The explanatory and response variables were assessed for correlation, followed by multivariable regression analyses adjusting for PHQ-9 and GAD-7 scores pre-pandemic as well as age, BMI, and parity. A higher CSI score and a greater number of chronic pain comorbidities before the pandemic were both positively correlated with PHQ-9 and GAD-7 scores during the pandemic. These associations remained significant in adjusted analyses. Increasing the CSI score by 10 was associated with an increase in pandemic PHQ-9 by 0. 74 points (p

Concepts Keywords
Covid anxiety
Nct02911090 central sensitization
Pandemic COVID-19
Therapy depression
endometriosis

Semantics

Type Source Name
disease MESH endometriosis
disease MESH COVID-19 pandemic
disease MESH central nervous system sensitization
disease VO population
disease MESH chronic pain

Original Article

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