Real-world effectiveness of the inactivated COVID-19 vaccines against variant of concerns: meta-analysis.

Real-world effectiveness of the inactivated COVID-19 vaccines against variant of concerns: meta-analysis.

Publication date: Feb 01, 2024

COVID-19 has killed over 6 million people worldwide, making it the worst global health disaster since the 1918 influenza pandemic. Experts have worked to establish the source, track and analyse the disease, and produce treatment and preventative guidelines. Inactivated vaccines have little evidence of efficacy compared to mRNA and adenoviral vector vaccines; however, three doses of both mRNA and inactivated vaccines appear to provide significant and lasting protection against severe disease and mortality. This study examines inactivated vaccine effectiveness data by disease status, age, gender, primary immunisation, booster doses, and SARS-CoV2 virus types. We conducted a quantitative epidemiological meta-analysis study to assess the vaccine effectiveness of inactivated COVID-19 vaccines. Data extraction was performed on the selected studies, and data analysis was conducted using a random-effects model to determine consolidated assessments of vaccine effectiveness. Subgroup analyses were conducted for gender, age, disease level, and vaccine status, and sensitivity analyses were conducted to assess the robustness of the results. The overall effect size of inactivated COVID-19 vaccinations was statistically significant (p-value

Concepts Keywords
Experts COVID-19
Influenza Inactivated SARS-CoV-2
Killed Odd ratio
Mrna Vaccine
Vaccinations

Semantics

Type Source Name
disease VO effectiveness
disease MESH COVID-19
disease MESH influenza
disease VO vaccine effectiveness
disease VO vaccine

Original Article

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