Comparison of COVID-19 and Influenza-Related Outcomes in the United States during Fall-Winter 2022-2023: A Cross-Sectional Retrospective Study.

Comparison of COVID-19 and Influenza-Related Outcomes in the United States during Fall-Winter 2022-2023: A Cross-Sectional Retrospective Study.

Publication date: Jan 03, 2024

Influenza and COVID-19 contribute significantly to the infectious disease burden during the respiratory season, but their relative burden remains unknown. This study characterizes the frequency and severity of medically attended COVID-19 and influenza during the peak of the 2022-2023 influenza season in the pediatric, adult, and older adult populations and characterizes the prevalence of underlying conditions among patients hospitalized with COVID-19. This cross-sectional analysis included individuals in the Veradigm EHR Database linked to Komodo claims data with a medical encounter between 1 October 2022 and 31 March 2023 (study period). Patients with medical encounters were identified with a diagnosis of COVID-19 or influenza during the study period and stratified based on the highest level of care received with that diagnosis. Among 23,526,196 individuals, there were more COVID-19-related medical encounters than influenza-related encounters, overall and by outcome. Hospitalizations with COVID-19 were more common than hospitalizations with influenza overall (incidence ratio = 4. 6) and in all age groups. Nearly all adults hospitalized with COVID-19 had at least one underlying medical condition, but 37. 1% of 0-5-year-olds and 25. 0% of 6-17-year-olds had no underlying medical conditions. COVID-19 was associated greater burden than influenza during the peak of the 2022-2023 influenza season.

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Concepts Keywords
Influenza COVID-19
October hospitalization
Pediatric influenza
Winter SARS-CoV-2
United States

Semantics

Type Source Name
disease MESH COVID-19
disease MESH Influenza
disease MESH infectious disease
pathway REACTOME Infectious disease
disease VO frequency
disease VO USA
drug DRUGBANK Coenzyme M
disease VO Canada
disease MESH infection
disease VO vaccine
disease VO Respiratory syncytial virus
disease VO dose
disease VO time
disease MESH asymptomatic infection
disease MESH emergency
disease MESH morbidity
disease MESH sequelae
disease MESH long COVID
disease IDO acute infection
disease MESH hypertension
disease VO vaccination
disease VO vaccine efficacy
disease VO population
disease VO effectiveness
disease MESH attention deficit hyperactivity disorder
disease MESH asthma
pathway KEGG Asthma
disease MESH cancer
disease MESH cerebral palsy
disease MESH cerebrovascular disease
disease MESH chronic kidney disease
disease MESH liver disease
disease MESH cystic fibrosis
disease MESH dementia
disease MESH syndrome
disease MESH heart disease
disease IDO immunodeficiency
disease MESH obesity
disease MESH tuberculosis
pathway KEGG Tuberculosis
disease MESH Mental disorders
disease MESH arthritis
disease MESH osteoporosis
disease MESH malformations

Original Article

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