Integrated analysis of RNA-seq datasets reveals novel targets and regulators of COVID-19 severity.

Integrated analysis of RNA-seq datasets reveals novel targets and regulators of COVID-19 severity.

Publication date: Apr 01, 2024

During the COVID-19 pandemic, RNA-seq datasets were produced to investigate the virus-host relationship. However, much of these data remains underexplored. To improve the search for molecular targets and biomarkers, we performed an integrated analysis of multiple RNA-seq datasets, expanding the cohort and including patients from different countries, encompassing severe and mild COVID-19 patients. Our analysis revealed that severe COVID-19 patients exhibit overexpression of genes coding for proteins of extracellular exosomes, endomembrane system, and neutrophil granules (e. g., S100A9, LY96, and RAB1B), which may play an essential role in the cellular response to infection. Concurrently, these patients exhibit down-regulation of genes encoding components of the T cell receptor complex and nucleolus, including TP53, IL2RB, and NCL Finally, SPI1 may emerge as a central transcriptional factor associated with the up-regulated genes, whereas TP53, MYC, and MAX were associated with the down-regulated genes during COVID-19. This study identified targets and transcriptional factors, lighting on the molecular pathophysiology of syndrome coronavirus 2 infection.

Concepts Keywords
Biomarkers Covid
Coronavirus Exhibit
Ly96 Including
Mild Infection
Overexpression Integrated
Molecular
Regulated
Regulators
Reveals
Rna
Seq
Severe
Targets
Tp53
Transcriptional

Semantics

Type Source Name
disease MESH COVID-19
disease IDO host
disease MESH infection
drug DRUGBANK Myricetin
disease MESH syndrome

Original Article

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