Multivariate patterns of brain functional connectome associated with COVID-19-related negative affect symptoms.

Multivariate patterns of brain functional connectome associated with COVID-19-related negative affect symptoms.

Publication date: Jan 22, 2024

Severe mental health problems with the representation of negative affect symptoms (NAS) have been increasingly reported during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to explore the multivariate patterns of brain functional connectome predicting COVID-19-related NAS. This cohort study encompassed a group of university students to undergo neuroimaging scans before the pandemic, and we re-contacted participants for 1-year follow-up COVID-related NAS evaluations during the pandemic. Regularized canonical correlation analysis was used to identify connectome-based dimensions of NAS to compute pairs of canonical variates. The predictive ability of identified functional connectome to NAS dimensional scores was examined with a nested cross-validation. Two dimensions (i. e. mode stress and mode anxiety) were related to distinct patterns of brain functional connectome (r = 0. 911, P = 0. 048; r = 0. 901, P = 0. 037, respectively). Mode anxiety was characterized by high loadings in connectivity between affective network (AFN) and visual network (VN), while connectivity of the default mode network with dorsal attention network (DAN) were remarkably prominent in mode stress. Connectivity patterns within the DAN and between DAN and VN, ventral attention network, and AFN was common for both dimensions. The identified functional connectome can reliably predict mode stress (r = 0. 37, MAE = 5. 1, p 

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Concepts Keywords
Coronavirus Brain
Psychiatry Connectivity
Students Connectome


Type Source Name
disease MESH COVID-19
disease VO organization
disease MESH Emergency
disease MESH burnout
disease MESH psychological trauma
disease IDO symptom
disease VO USA
drug DRUGBANK Coenzyme M
disease MESH abnormalities
disease IDO history
disease MESH infection
disease VO protocol
disease IDO susceptibility
drug DRUGBANK Albendazole
disease IDO process
disease MESH Syndrome
disease MESH Phobia
disease MESH Vicarious Traumatization
disease MESH Uncertainty
disease MESH Death
disease MESH PTSD
drug DRUGBANK Indoleacetic acid
drug DRUGBANK Huperzine B
disease VO age
disease MESH mental disorders
disease VO report
disease MESH Lifestyle
disease VO population
drug DRUGBANK Guanosine
disease MESH attention deficit hyperactivity disorder
drug DRUGBANK L-Phenylalanine
disease VO organ
disease MESH insomnia disorder
disease MESH major depressive disorder
drug DRUGBANK Serine
disease IDO replication
disease MESH psychosis
disease MESH schizophrenia
disease MESH mood disorders
disease VO volume
disease MESH obesity
disease MESH loneliness
drug DRUGBANK Ethanol
disease MESH bipolar disorder
disease MESH traumatic stress disorders
drug DRUGBANK Serotonin
drug DRUGBANK Psilocybine
disease MESH cognitive impairment
disease MESH anosognosia

Original Article

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