RETINAL VASCULAR OCCLUSION AND COVID-19 DIAGNOSIS: A Multicenter Population-Based Study.

RETINAL VASCULAR OCCLUSION AND COVID-19 DIAGNOSIS: A Multicenter Population-Based Study.

Publication date: Feb 01, 2024

Several ocular diseases have been reported in patients with coronavirus disease 2019 (COVID-19), especially retinal vascular occlusion. This study aimed to examine the risk of retinal vascular occlusion after COVID-19 diagnosis. This retrospective cohort study was based on 46 health care organizations in the United States using the TriNetX network. Individuals who had laboratory confirmation of COVID-19 from January 1, 2020, to December 31, 2021, were included. Multivariate analysis was adjusted on age, sex, race, and comorbidities, and hazard ratio was calculated using the Cox proportional hazard regression model. A total of 1,460,634 paired individuals were enrolled for analysis. Patients with COVID-19 had a significantly higher risk of branch retinal vein occlusion (hazard ratio 1. 27, 95% confidence interval [CI] 1. 04-1. 52) than those without COVID-19. The cumulative incidence rate of branch retinal vein occlusion was also significantly higher in patients with COVID-19 compared with those without COVID-19 (log-rank P = 0. 014). Within 12 weeks after COVID-19 diagnosis, the transient effect of central retinal vein occlusion (hazard ratio 1. 59, 95% confidence interval 1. 15-2. 17) and branch retinal vein occlusion (hazard ratio 2. 11, 95% confidence interval 1. 51-2. 95) were observed. This large-scale multicenter study demonstrated that retinal vein occlusion may be associated with COVID-19.

Concepts Keywords
Coronavirus Based
December Branch
Laboratory Confidence
Covid
Diagnosis
Hazard
Individuals
Interval
Multicenter
Occlusion
Ratio
Retinal
Risk
Vascular
Vein

Semantics

Type Source Name
disease MESH COVID-19
disease VO population
disease MESH branch retinal vein occlusion

Original Article

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