Respiratory Syncytial Virus-Associated Deaths among Children under Five before and during the COVID-19 Pandemic in Bangladesh.

Respiratory Syncytial Virus-Associated Deaths among Children under Five before and during the COVID-19 Pandemic in Bangladesh.

Publication date: Jan 12, 2024

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infections in young children worldwide. RSV-associated deaths in children are underreported in Bangladesh. We analyzed hospital-based surveillance data on severe acute respiratory infections (SARIs) in under-five children before (August 2009-February 2020) and during the COVID-19 pandemic (March 2020-March 2022). Using the World Health Organization definition, we identified SARI cases in 14 tertiary-level hospitals. Nasopharyngeal and oropharyngeal swabs were collected for real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) testing of six respiratory viruses, including RSV. SARI deaths during the pandemic (2. 6%, 66) were higher than pre-pandemic (1. 8%, 159; p < 0. 001). Nearly half of pandemic deaths (47%) had underlying respiratory viruses, similar to the pre-pandemic rate (45%). RSV detection in deaths was consistent pre-pandemic (13%, 20/159) and during the pandemic (12%, 8/66). Children aged < 6 months constituted 57% (16) of RSV-related deaths. Evaluating interventions like maternal vaccination and infant monoclonal antibody prophylaxis is crucial to address RSV, a major contributor to under-five SARI deaths.

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Concepts Keywords
Bangladesh Bangladesh
February Bangladesh
Pandemic Child
Vaccination Child, Preschool
COVID-19 pandemic
respiratory syncytial virus
Respiratory Tract Infections
SARI death
Tertiary Care Centers


Type Source Name
disease VO Respiratory syncytial virus
disease MESH COVID-19 Pandemic
disease MESH respiratory infections
disease VO organization
disease VO time
disease VO Viruses
disease VO vaccination
drug DRUGBANK Coenzyme M
disease MESH death
disease MESH infection
disease VO nose
disease MESH complications
disease MESH bronchiolitis
disease MESH inflammation
disease MESH pneumonia
disease MESH ear infections
disease VO Gap
disease MESH morbidity
disease VO effective
disease VO population
disease MESH influenza
drug DRUGBANK Etoperidone
drug DRUGBANK Methionine
disease IDO history
disease IDO quality
disease MESH hypertension
disease MESH cancer
disease MESH asthma
pathway KEGG Asthma
disease MESH chronic obstructive pulmonary disease
disease MESH heart diseases
disease IDO facility
drug DRUGBANK Nitrogen
disease IDO site
disease VO Metapneumovirus
disease MESH parainfluenza
disease VO USA
disease IDO assay
disease VO Tat
drug DRUGBANK Trihexyphenidyl
drug DRUGBANK Thiocolchicoside
drug DRUGBANK 5-amino-1 3 4-thiadiazole-2-thiol
disease VO TTC

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