Restoring immune tolerance in pemphigus vulgaris.

Restoring immune tolerance in pemphigus vulgaris.

Publication date: Jan 30, 2024

Intravenous immunoglobulin (IVIg), a preparation of polyclonal serum IgG pooled from numerous blood donors, has been used for nearly three decades and is proving to be an efficient treatment for many autoimmune blistering diseases, including pemphigus vulgaris (PV). Despite its widespread use and therapeutic success, its mechanisms of action are not completely understood. Some of its anti-inflammatory and immunomodulatory actions have been studied. In this study, the authors present a twenty-year follow-up of 21 patients with clinical and immunopathological confirmed PV, treated with IVIg as monotherapy, according to an established published protocol. IVIg therapy produced long-term sustained, clinical, serological, and immunopathological remission. For 20 y, these patients received no drugs and experienced no disease. This observation suggests that there was the establishment of immune balance or restoration of immune regulation in these PV patients. Twelve (57%) patients experienced no relapse during follow-up. Six (29%) patients experienced a relapse due to acute stress or post-coronavirus infection and/or vaccination. Reinstitution of IVIg resulted in prompt sustained recovery. Three (14. 2%) patients, in clinical and serological remission, died due to unrelated causes. No severe adverse effects from IVIg were documented in all 21 patients. The simultaneous or sequential anti-inflammatory and immunomodulatory effects of IVIg may have influenced the long-term clinical remission observed. This study provides a human prototype to examine the pathophysiology of autoimmunity and a model to study immune regulation and mechanisms that can facilitate restoring immune tolerance.

Concepts Keywords
Coronavirus immune tolerance
Decades intravenous immunoglobulin
Efficient long-term remission
Pathophysiology pemphigus vulgaris
Vaccination twenty-year follow-up

Semantics

Type Source Name
disease MESH immune tolerance
disease MESH pemphigus vulgaris
drug DRUGBANK Immune Globulin Human
disease IDO blood
disease VO efficient
drug DRUGBANK Spinosad
disease VO protocol
drug DRUGBANK Isoxaflutole
disease MESH coronavirus infection
disease VO vaccination
disease MESH causes
disease MESH autoimmunity

Original Article

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