Association of the C allele of rs479200 in the EGLN1 gene with COVID-19 severity in Indian population: a novel finding.

Publication date: Jan 30, 2024

The present study investigated two single nucleotide polymorphisms (SNPs)-rs479200 and rs516651 in the host EGLN1/PHD2 gene for their association with COVID-19 severity. A retrospective cohort of 158 COVID-19 patients from the Indian population (March 2020 to June 2021) was enrolled. Notably, the frequency of C allele (0. 664) was twofold higher than T allele (0. 336) in severe COVID-19 patients. Here, we report a novel finding that the C allele of rs479200 in the EGLN1 gene imparts a high risk of severe COVID-19 (odds ratio-6. 214 (1. 84-20. 99) pā€‰=ā€‰0. 003; 9. 421 (2. 019-43. 957) pā€‰=ā€‰0. 004), in additive inheritance model (adjusted and unadjusted, respectively).

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Concepts Keywords
Allele COVID-19
June EGLN1 gene
Phd2 Host genetic factors
Rs479200 Hypoxia
Risk factors
rs479200
rs516651

Semantics

Type Source Name
disease VO gene
disease MESH COVID-19
disease VO population
disease IDO host
disease VO frequency
disease VO report
disease MESH Long Covid
pathway REACTOME Reproduction
disease VO Severe acute respiratory syndrome coronavirus 2
disease MESH complications
disease MESH pneumonia
disease MESH hypocapnia
disease MESH hypercapnia
disease MESH edema
drug DRUGBANK Oxygen
drug DRUGBANK Angiotensin II
drug DRUGBANK Serine
drug DRUGBANK Coenzyme M
disease MESH Malaria
pathway KEGG Malaria
disease VO inactivation
disease MESH infection
disease IDO blood
drug DRUGBANK Ademetionine
drug DRUGBANK Pentaerythritol tetranitrate
disease IDO facility
disease IDO homo sapiens
drug DRUGBANK 7-Methyl-Gpppa
disease MESH RFLP
disease VO USA
disease IDO assay
disease MESH causes
disease VO URE
drug DRUGBANK Esomeprazole
disease MESH cytokine storms
disease VO time
disease VO Pal
disease MESH Infectious Diseases
disease MESH Dengue
disease MESH acute respiratory distress syndrome
disease MESH pulmonary edema
disease MESH Hypospadias
disease IDO susceptibility
disease MESH preeclampsia
disease MESH lung injury

Original Article

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