Mismatch between subjective and objective dysautonomia.

Publication date: Jan 30, 2024

Autonomic symptom questionnaires are frequently used to assess dysautonomia. It is unknown whether subjective dysautonomia obtained from autonomic questionnaires correlates with objective dysautonomia measured by quantitative autonomic testing. The objective of our study was to determine correlations between subjective and objective measures of dysautonomia. This was a retrospective cross-sectional study conducted at Brigham and Women’s Faulkner Hospital Autonomic Laboratory between 2017 and 2023 evaluating the patients who completed autonomic testing. Analyses included validated autonomic questionnaires [Survey of Autonomic Symptoms (SAS), Composite Autonomic Symptom Score 31 (Compass-31)] and standardized autonomic tests (Valsalva maneuver, deep breathing, sudomotor, and tilt test). The autonomic testing results were graded by a Quantitative scale for grading of cardiovascular reflexes, sudomotor tests and skin biopsies (QASAT), and Composite Autonomic Severity Score (CASS). Autonomic testing, QASAT, CASS, and SAS were obtained in 2627 patients, and Compass-31 in 564 patients. The correlation was strong between subjective instruments (SAS vs. Compass-31, r = 0. 74, p 

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Concepts Keywords
Biopsies Autonomic
Brigham Compass
Cardiovascular Composite
Dysautonomia Dysautonomia
Women Objective


Type Source Name
disease MESH dysautonomia
disease IDO symptom
disease MESH Long Covid
drug DRUGBANK Coenzyme M
disease MESH sequelae
disease MESH COVID 19
disease MESH postural tachycardia syndrome
disease MESH myalgic encephalomyelitis
disease MESH syndrome
disease MESH Ehlers Danlos syndrome
disease MESH orthostatic hypotension
disease VO population
disease VO time
disease VO USA
disease MESH Mastocytosis
disease MESH diabetic neuropathy
drug DRUGBANK L-Aspartic Acid
disease MESH orthostatic intolerance
disease VO report
disease IDO history
disease MESH syncope
disease IDO blood
disease MESH asthma
pathway KEGG Asthma
drug DRUGBANK Nicotine
drug DRUGBANK Caffeine
drug DRUGBANK Ethanol
disease MESH neurological disorders
disease MESH small fiber neuropathy
disease MESH abnormalities
drug DRUGBANK Acetylcholine
disease IDO algorithm
disease MESH hypotension
drug DRUGBANK Esomeprazole
disease VO urinary bladder
disease IDO entity
disease VO Rho
disease MESH clinical significance
drug DRUGBANK Naproxen
disease MESH synucleinopathies
disease MESH pure autonomic failure
disease MESH multiple system atrophy
drug DRUGBANK Dextrose unspecified form
disease MESH autism
disease MESH job stress
disease MESH fibromyalgia
disease MESH central sensitization
disease MESH Allergy
pathway REACTOME Reproduction

Original Article

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