Profiles of Cough and Associated Risk Factors in Nonhospitalized Individuals With SARS-CoV-2 Omicron Variant Infection: Cross-Sectional Online Survey in China.

Publication date: Feb 05, 2024

Cough is a common symptom during and after COVID-19 infection; however, few studies have described the cough profiles of COVID-19. The aim of this study was to investigate the prevalence, severity, and associated risk factors of severe and persistent cough in individuals with COVID-19 during the latest wave of the Omicron variant in China. In this nationwide cross-sectional study, we collected information of the characteristics of cough from individuals with infection of the SARS-CoV-2 Omicron variant using an online questionnaire sent between December 31, 2022, and January 11, 2023. There were 11,718 (n=7978, 68. 1% female) nonhospitalized responders, with a median age of 37 (IQR 30-47) years who responded at a median of 16 (IQR 12-20) days from infection onset to the time of the survey. Cough was the most common symptom, occurring in 91. 7% of participants, followed by fever, fatigue, and nasal congestion (68. 8%-87. 4%). The median cough visual analog scale (VAS) score was 70 (IQR 50-80) mm. Being female (odds ratio [OR] 1. 31, 95% CI 1. 20-1. 43), having a COVID-19 vaccination history (OR 1. 71, 95% CI 1. 37-2. 12), current smoking (OR 0. 48, 95% CI 0. 41-0. 58), chronic cough (OR 2. 04, 95% CI 1. 69-2. 45), coronary heart disease (OR 1. 71, 95% CI 1. 17-2. 52), asthma (OR 1. 22, 95% CI 1. 02-1. 46), and gastroesophageal reflux disease (GERD) (OR 1. 21, 95% CI 1. 01-1. 45) were independent factors for severe cough (VAS>70, 37. 4%). Among all respondents, 35. 0% indicated having a productive cough, which was associated with risk factors of being female (OR 1. 44, 95% CI 1. 31-1. 57), having asthma (OR 1. 84, 95% CI 1. 52-2. 22), chronic cough (OR 1. 44, 95% CI 1. 19-1. 74), and GERD (OR 1. 22, 95% CI 1. 01-1. 47). Persistent cough (>3 weeks) occurred in 13. 0% of individuals, which was associated with the risk factors of having diabetes (OR 2. 24, 95% CI 1. 30-3. 85), asthma (OR 1. 70, 95% CI 1. 11-2. 62), and chronic cough (OR 1. 97, 95% CI 1. 32-2. 94). Cough is the most common symptom in nonhospitalized individuals with Omicron SARS-CoV-2 variant infection. Being female, having asthma, chronic cough, GERD, coronary heart disease, diabetes, and a COVID-19 vaccination history emerged as independent factors associated with severe cough, productive cough, and persistent cough.

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Concepts Keywords
China cough
December COVID-19
Diabetes nonhospitalized
Smoking Omicron variant

Semantics

Type Source Name
disease MESH Infection
disease IDO symptom
disease MESH COVID-19
disease VO time
disease VO vaccination
disease IDO history
disease MESH coronary heart disease
disease MESH asthma
pathway KEGG Asthma
disease MESH gastroesophageal reflux disease
disease MESH Long Covid
disease MESH Respiratory Diseases
drug DRUGBANK Coenzyme M
disease MESH sore throat
disease MESH chest pain
disease VO organization
disease MESH mental illness
disease VO device
disease MESH arthralgia
disease VO nose
disease MESH conjunctivitis
disease MESH common cold
disease VO frequency
disease MESH rhinitis
disease MESH sinusitis
disease MESH hypertension
disease MESH chronic urticaria
disease MESH dermatitis
disease MESH tumor
disease MESH urticaria
disease VO vaccine
disease MESH chronic obstructive pulmonary disease

Original Article

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