Impact of COVID-19 on the development of major mental disorders in patients visiting a university hospital: a retrospective observational study.

Publication date: Feb 06, 2024

This study aimed to investigate the impact of coronavirus disease 2019 (COVID-19) on the development of major mental disorders in patients visiting a university hospital. The study participants were patients with COVID-19 (n=5,006) and those without COVID-19 (n=367,162) registered in the database of Keimyung University Dongsan Hospital and standardized with the Observational Medical Outcomes Partnership Common Data Model. Data on major mental disorders that developed in both groups over the 5-year follow-up period were extracted using the FeederNet computer program. A multivariate Cox proportional hazards model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for the incidence of major mental disorders. The incidences of dementia and sleep, anxiety, and depressive disorders were significantly higher in the COVID-19 group than in the control group. The incidence rates per 1,000 patient-years in the COVID-19 group vs. the control group were 12. 71 vs. 3. 76 for dementia, 17. 42 vs. 7. 91 for sleep disorders, 6. 15 vs. 3. 41 for anxiety disorders, and 8. 30 vs. 5. 78 for depressive disorders. There was no significant difference in the incidence of schizophrenia or bipolar disorder between the two groups. COVID-19 infection increased the risk of mental disorders in the following order: dementia (HR, 3. 49; 95% CI, 2. 45-4. 98), sleep disorders (HR, 2. 27; 95% CI, 1. 76-2. 91), anxiety disorders (HR, 1. 90; 95% CI, 1. 25-2. 84), and depressive disorders (HR, 1. 54; 95% CI, 1. 09-2. 15). This study showed that the major mental disorders associated with COVID-19 were dementia and sleep, anxiety, and depressive disorders.

Concepts Keywords
Coronavirus Big data
Covid Cohort studies
Dementia Common Data Medel
Hospital COVID-19
Mental disorders


Type Source Name
disease MESH COVID-19
disease MESH mental disorders
disease MESH dementia
disease MESH depressive disorders
disease MESH sleep disorders
disease MESH anxiety disorders
disease MESH schizophrenia
disease MESH bipolar disorder
disease MESH infection
disease MESH Long Covid

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