Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant.

Publication date: Feb 08, 2024

Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence of XBB. 1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB. 1.5 evolved from XBB. 1 by acquiring the S486P spike (S) mutation, subsequent to the acquisition of a nonsense mutation in ORF8. Neutralization assays showed similar abilities of immune escape between XBB. 1.5 and XBB. 1. We determine the structural basis for the interaction between human ACE2 and the S protein of XBB. 1.5, showing similar overall structures between the S proteins of XBB. 1 and XBB. 1.5. We provide the intrinsic pathogenicity of XBB. 1 and XBB. 1.5 in hamsters. Importantly, we find that the ORF8 nonsense mutation of XBB. 1.5 resulted in impairment of MHC suppression. In vivo experiments using recombinant viruses reveal that the XBB. 1.5 mutations are involved with reduced virulence of XBB. 1.5. Together, our study identifies the two viral functions defined the difference between XBB. 1 and XBB. 1.5.

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Concepts Keywords
Hamsters Characteristics
Pathogenicity Circulation
Recombinant Cov
Viral Emergence
Virulence Interest


Type Source Name
disease MESH nonsense mutation
disease VO Viruses
disease IDO virulence
disease MESH COVID 19
disease VO vaccination
drug DRUGBANK Protein S human
disease VO USA
disease MESH infection
disease IDO history
drug DRUGBANK Coenzyme M
disease VO effective
pathway REACTOME Reproduction
drug DRUGBANK Pentaerythritol tetranitrate
disease VO vaccine
disease VO dose

Original Article

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