Vaccination and the risk of post-acute sequelae after COVID-19 In the Omicron-predominant period.

Publication date: Feb 06, 2024

To assess the association of primary and third doses of vaccination with the risk of post-acute sequelae of COVID-19. This retrospective cohort study utilized a combined database of nationwide healthcare claims data, COVID-19 patient registry, and vaccination records from South Korea. Individuals diagnosed with COVID-19 in the Omicron variant-dominant period of January to March 2022 were tracked for 30-120 days post-infection. The exposure of interest was the receipt of primary and third doses of the SARS-CoV-2 vaccine. The occurrence of 26 specific conditions in eight domains was compared using Cox regression with inverse probability of treatment weighting. This study included 394,773 unvaccinated individuals and 7,604,081 individuals receiving ≥2 doses of vaccine. Compared with unvaccinated individuals, vaccination with at least two doses was associated with a reduced risk (adjusted hazard ratio; 95% confidence interval) of several conditions, including ischemic heart disease (0. 73; 0. 57-0. 94), heart failure (0. 55; 0. 48-0. 63), cardiac dysrhythmia (0. 72; 0. 61-0. 85), cardiac arrest (0. 41; 0. 33-0. 51), pulmonary embolism (0. 66; 0. 52-0. 84), venous thromboembolism (0. 54; 0. 44-0. 66), acute renal failure (0. 56; 0. 46-0. 67), new dialysis (0. 45; 0. 34-0. 59), chronic obstructive pulmonary disease (0. 74; 0. 65-0. 84), acute pancreatitis (0. 64; 0. 51-0. 80), and diabetes (0. 82; 0. 71-0. 95). The risks of heart failure, cardiac dysrhythmias, cardiac arrest, pulmonary embolism, and new dialysis were lower in those vaccinated with three doses compared with two doses. Vaccination was associated with a decreased risk of post-acute sequelae of COVID-19, suggesting its potential role in mitigating the indirect impacts of COVID-19.

Concepts Keywords
Diabetes combined database
Dysrhythmias COVID-19
Korea Retrospective cohort study
Vaccinated Vaccination


Type Source Name
disease VO vaccination
disease MESH sequelae
disease MESH COVID-19
disease MESH infection
disease VO vaccine
disease VO unvaccinated
disease MESH ischemic heart disease
disease MESH heart failure
disease MESH cardiac dysrhythmia
disease MESH cardiac arrest
disease MESH pulmonary embolism
disease MESH venous thromboembolism
disease MESH acute renal failure
disease MESH chronic obstructive pulmonary disease
disease MESH acute pancreatitis
disease VO vaccinated

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