Impact of influenza vaccination history in the clinical course of older adults hospitalized with COVID-19.

Publication date: Feb 10, 2024

Some studies have shown that influenza vaccination is associated with a lower risk of SARS-CoV-2 infection; in patients with COVID-19 infection, admission to intensive care is reduced, with less need for mechanical ventilation, shorter hospital stays, and reduced mortality. This study aimed to determine if a history of annual influenza vaccination impacts the clinical course of SARS-CoV-2 infection during hospitalization. This was an observational, prospective, cohort study of patients older than 65 admitted to the COVID-19 unit from January to June 2021. The history of influenza vaccination over the last 5 years was assessed in each patient during hospitalization. We measured the length of hospital stay, the need for admission to the intensive care unit (ICU), the patient’s oxygen requirements, complications during hospitalization, and outcome (medical discharge or death). Patients with a history of vaccination against SARS-CoV-2 were not included. We analyzed 125 patients, 50. 4% (n=63) with history of influenza vaccination and 49. 6% (n=62) without a history of influenza vaccination. In-hospital mortality was 44. 8%, higher in the unvaccinated (54. 8%) population (p=0. 008). ICU admission was 27% higher in vaccinated (35%) patients (p=0. 05). Patients without a history of influenza vaccination had a higher prevalence of cardiac (8% vs. 5%, p=0. 04) and renal complications (29% vs. 13%, p=0. 02). Patients with a history of vaccination had a greater need for invasive mechanical ventilation (25. 4%, p=0. 02). In this study, a history of influenza vaccination in older adults with SARS-CoV-2 infection was related to lower in-hospital mortality.

Concepts Keywords
Influenza Adultos mayores
Invasive COVID-19
June Influenza
Vaccinated Older adults


Type Source Name
disease MESH influenza
disease VO vaccination
disease IDO history
disease MESH clinical course
disease MESH COVID-19
pathway REACTOME SARS-CoV-2 Infection
disease MESH infection
drug DRUGBANK Oxygen
disease MESH complications
disease MESH death
disease VO unvaccinated
disease VO population
disease VO vaccinated

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