Persistent Shortness of Breath in Post-COVID-19 Patients: Inducible Laryngeal Obstruction Can Be a Cause.

Publication date: Feb 22, 2024

Inducible laryngeal obstruction (ILO) is the adduction of the true vocal folds during inspiration or, less frequently, expiration. Its etiology is unknown. This study aimed to identify ILO as a possible cause of shortness of breath (SOB) in post-COVID-19 patients. A retrospective study was conducted on 59 post-COVID-19 adults complaining of SOB. We collected the cases’ clinical and chest imaging data, including demographic data, pulmonary function test (PFT), CT chest, and laryngeal endoscopic examination. A visual score was used to assign the severity of the glottic obstruction. The grades of this score ranged from 0 (complete patency) to 3 (almost complete closure). ILO was detected in 8 out of 59 cases (13. 5%). Two cases out of eight had glottic closure grade 1, while five cases had glottic closure grade 2, and one had glottic closure grade 3. There was a positive correlation between ILO grades (the severity of glottic closure) and PFT results (the degree of upper airway restriction). PFTs in ILO have a specific pattern. It was typical for the expiratory loop to be normal and the inspiratory loop to be flattened. ILO is a possible cause of SOB in post-COVID-19 adult cases. It should be considered during evaluation and management.

Concepts Keywords
Adults Induced laryngeal obstruction
Laryngeal Post COVID-19
Pulmonary Shortness of breath


Type Source Name
disease MESH COVID-19
disease MESH etiology
drug DRUGBANK Bentiromide

Original Article

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