Neutralizing antibodies after the third COVID-19 vaccination in healthcare workers with or without breakthrough infection.

Publication date: Feb 23, 2024

Vaccinations against the SARS-CoV-2 are still crucial in combating the ongoing pandemic that has caused more than 700 million infections and claimed almost 7 million lives in the past four years. Omicron (B. 1.1. 529) variants have incurred mutations that challenge the protection against infection and severe disease by the current vaccines, potentially compromising vaccination efforts. We analyzed serum samples taken up to 9 months post third dose from 432 healthcare workers. Enzyme-linked immunosorbent assays (ELISA) and microneutralization tests (MNT) were used to assess the prevalence of vaccine-induced neutralizing antibodies against various SARS-CoV-2 Omicron variants. In this serological analysis we show that SARS-CoV-2 vaccine combinations of BNT162b2, mRNA-1273, and ChAdOx1 mount SARS-CoV-2 binding and neutralizing antibodies with similar kinetics, but with differing neutralization capabilities. The most recent Omicron variants, BQ. 1.1 and XBB. 1.5, show a significant increase in the ability to escape vaccine and infection-induced antibody responses. Breakthrough infections in thrice vaccinated adults were seen in over 50% of the vaccinees, resulting in a stronger antibody response than without infection. Different three-dose vaccine combinations seem to induce considerable levels of neutralizing antibodies against most SARS-CoV-2 variants. However, the ability of the newer variants BQ1. 1 and XBB 1. 5 to escape vaccine-induced neutralizing antibody responses underlines the importance of updating vaccines as new variants emerge.

Concepts Keywords
Bnt162b2 Antibodies
Pandemic Antibody
Vaccinees Breakthrough
Workers Cov


Type Source Name
disease MESH COVID-19
disease VO vaccination
disease MESH breakthrough infection
disease MESH infections
disease IDO infection
disease VO dose
disease VO vaccine
disease VO vaccinated

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