Optimization of Screening Strategies for COVID-19: Scoping Review.

Publication date: Feb 27, 2024

COVID-19 screening is an effective nonpharmaceutical intervention for identifying infected individuals and interrupting viral transmission. However, questions have been raised regarding its effectiveness in controlling the spread of novel variants and its high socioeconomic costs. Therefore, the optimization of COVID-19 screening strategies has attracted great attention. This review aims to summarize the evidence and provide a reference basis for the optimization of screening strategies for the prevention and control of COVID-19. We applied a methodological framework for scoping reviews and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) checklist. We conducted a scoping review of the present publications on the optimization of COVID-19 screening strategies. We searched the PubMed, Web of Science, and Elsevier ScienceDirect databases for publications up to December 31, 2022. English publications related to screening and testing strategies for COVID-19 were included. A data-charting form, jointly developed by 2 reviewers, was used for data extraction according to the optimization directions of the screening strategies. A total of 2770 unique publications were retrieved from the database search, and 95 abstracts were retained for full-text review. There were 62 studies included in the final review. We summarized the results in 4 major aspects: the screening population (people at various risk conditions such as different regions and occupations; 12/62, 19%), the timing of screening (when the target population is tested before travel or during an outbreak; 12/62, 19%), the frequency of screening (appropriate frequencies for outbreak prevention, outbreak response, or community transmission control; 6/62, 10%), and the screening and detection procedure (the choice of individual or pooled detection and optimization of the pooling approach; 35/62, 56%). This review reveals gaps in the optimization of COVID-19 screening strategies and suggests that a number of factors such as prevalence, screening accuracy, effective allocation of resources, and feasibility of strategies should be carefully considered in the development of future screening strategies.

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Concepts Keywords
December antigen test
Methodological COVID-19
Pooling optimization
Sciencedirect screening strategy


Type Source Name
disease MESH COVID-19
disease VO effective
disease IDO intervention
disease VO effectiveness
disease VO population
disease VO frequency
disease VO Canada
drug DRUGBANK Coenzyme M
disease MESH infections
disease IDO symptom
disease VO ineffective
disease MESH asymptomatic infections
disease VO efficiency
disease IDO contact tracing
drug DRUGBANK Gold
disease IDO infection
disease IDO process
disease VO Severe acute respiratory syndrome coronavirus 2
disease VO gene
disease VO document
disease VO organization
disease VO vaccinated
disease MESH morbidity
disease IDO country
disease VO vaccination
disease VO dead
drug DRUGBANK Etoperidone
disease IDO facility
disease VO unvaccinated
disease MESH causes
disease VO nose
drug DRUGBANK Fenofibrate
pathway REACTOME Reproduction
disease VO time
disease VO biweekly
disease IDO infectivity
disease VO volume
disease IDO algorithm
disease MESH emerging infectious diseases
disease MESH infectious diseases
pathway KEGG Coronavirus disease
disease VO organ
disease MESH back to work
disease IDO replication
drug DRUGBANK Nordazepam
drug DRUGBANK (S)-Des-Me-Ampa

Original Article

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