A Novel Anti-nucleocapsid Antibody Avidity Method for Identifying SARS-CoV-2 Reinfections.

Publication date: Mar 05, 2024

Detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections is challenging with current serology assays and is further complicated by the marked decrease in routine viral testing practices as viral transmission increased during Omicron. Here, we provide proof-of-principle that high-avidity anti-nucleocapsid (N) antibodies detects reinfections after a single infection with higher specificity (85%; 95% confidence interval [95% CI], 80%-90%) compared to anti-N antibody levels (72%; 95% CI, 66%-79%) in a vaccinated cohort. This method could be used to retroactively investigate the epidemiology and incremental long-term health consequences of SARS-CoV-2 reinfections.

Concepts Keywords
Antibodies avidity
Coronavirus COVID-19
Epidemiology nucleocapsid
Routine reinfection


Type Source Name
disease MESH Reinfections
disease VO Severe acute respiratory syndrome coronavirus 2
disease MESH infection
disease VO vaccinated
disease MESH COVID-19

Original Article

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