Impact of respiratory viral infections on nasopharyngeal pneumococcal colonization dynamics in children.

Publication date: Mar 05, 2024

Prevention of acute respiratory illnesses (ARI) in children is a global health priority, as these remain a leading cause of pediatric morbidity and mortality throughout the world. As new products and strategies to prevent respiratory infections caused by important pathogens such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza, respiratory syncytial virus and pneumococcus are advancing, increasing evidence suggests that these and other respiratory viruses and pneumococci may exhibit interactions that are associated with altered colonization and disease dynamics. We aim to review recent data evaluating interactions between respiratory viruses and pneumococci in the upper respiratory tract and their potential impact on pneumococcal colonization patterns and disease outcomes. While interactions between influenza infection and subsequent increased susceptibility and transmissibility of colonizing pneumococci have been widely reported in the literature, emerging evidence suggests that human rhinovirus, SARS-CoV-2, and other viruses may also exhibit interactions with pneumococci and alter pneumococcal colonization patterns. Additionally, colonizing pneumococci may play a role in modifying outcomes associated with respiratory viral infections. Recent evidence suggests that vaccination with pneumococcal conjugate vaccines, and prevention of colonization with pneumococcal serotypes included in these vaccines, may be associated with reducing the risk of subsequent viral infection and the severity of the associated illnesses. Understanding the direction and dynamics of viral-pneumococcal interactions may elucidate the potential effects of existing and emerging viral and bacterial vaccines and other preventive strategies on the health impact of these important respiratory pathogens.

Concepts Keywords
Bacterial Acute
Coronavirus Colonization
Global Dynamics
Understanding Evidence
Vaccination Illnesses


Type Source Name
disease MESH viral infections
disease MESH morbidity
disease MESH respiratory infections
disease VO Severe acute respiratory syndrome coronavirus 2
disease MESH influenza
disease VO Respiratory syncytial virus
disease VO Viruses
pathway REACTOME Influenza Infection
disease IDO susceptibility
disease VO vaccination

Original Article

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