Sinus venosus atrial septal defect presenting with platypnea-orthodeoxia syndrome in the setting of COVID-19 infection.

Publication date: Mar 05, 2024

Platypnea-orthodeoxia syndrome is characterised by hypoxemia and dyspnoea while upright that resolves when supine, typically associated with an interatrial communication. We present a case of platypnea-orthodeoxia syndrome associated with a sinus venosus atrial septal defect in a patient with multiple possible aetiologies of hypoxemia, including COVID-19 infection. Cardiac catheterisation with provocative maneuvers confirmed the diagnosis and symptoms resolved following defect closure. We suggest that in patients with platypnea-orthodeoxia syndrome, it is useful to obtain haemodynamic data while supine and upright.

Concepts Keywords
Cardiac Atrial septal defect
Cardiol COVID-19
Hypoxemia hypoxaemia
Interatrial platypnea-orthodeoxia


Type Source Name
disease MESH atrial septal defect
disease MESH platypnea-orthodeoxia syndrome
disease MESH COVID-19
disease MESH infection

Original Article

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