COVID 19 vaccination as a trigger of acute genital ulcers in an immunocompromised adolescent-case study and literature review.

Publication date: Mar 05, 2024

Acute genital ulcers can affect females of all ages. In children, they often appear as an emergency and remain a diagnostic challenge for pediatricians, gynecologists and dermatologists. Prompt diagnosis and identification of disease- related factors help to implement appropriate treatment. Firstly, it is crucial to properly compile the past medical history of the patient. Past infectious, autoimmune, malignant or traumatic conditions, as well as vaccinations may contribute to the occurrence of acute genital ulcers. Moreover, new infectious agents, such as severe acute respiratory syndrome coronavirus 2 and vaccinations against Coronavirus disease of 2019, may play a significant role in the development of atypical clinical symptoms. Here we present a case of a 12-year-old girl with acute genital ulcers. Additional symptoms accompanying the ulcer included: abdominal pain, nausea, vomiting, dysuria, vulvar pain and fever. Blood test showed leukocytosis, especially neutrophilia and monocytosis and increased levels of c-reactive protein and procalcitonin. Serological tests for the most common infections were negative. Moreover, the patient had a history of autoimmune diseases. She had periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome, and IgA vasculitis, also known as Henoch-SchcF6nlein purpura in her past medical history. Additionally, she was vaccinated against SARS-CoV-2 shortly before the lesions appeared.

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Concepts Keywords
Agents Acute genital ulcers
Coronavirus Adolescents
Gynecologists And adenitis syndrome
Malignant Aphthous stomatitis
Behcet’s disease
Lipschütz ulcers
Periodic fever


Type Source Name
disease MESH COVID 19
disease VO vaccination
disease MESH ulcers
disease MESH emergency
disease IDO history
disease VO Severe acute respiratory syndrome coronavirus 2
pathway KEGG Coronavirus disease
disease IDO blood
disease MESH leukocytosis
disease MESH infections
disease MESH autoimmune diseases
disease MESH aphthous stomatitis
disease MESH pharyngitis
disease MESH adenitis
disease MESH syndrome
disease MESH IgA vasculitis
disease MESH purpura
disease VO vaccinated
disease MESH Behcet’s disease
disease VO coronavirus vaccine
disease MESH etiology
disease MESH sexually transmitted disease
disease IDO infection
pathway REACTOME Reproduction
drug DRUGBANK Coenzyme M
disease MESH infectious disease
disease MESH infectious mononucleosis
disease MESH malignancy
disease VO population
disease MESH viral diseases
disease VO Viruses
disease MESH CMV inclusions
drug DRUGBANK Trestolone
drug DRUGBANK Adenosine
disease MESH bleeding
disease VO laboratory test
disease MESH abnormalities
drug DRUGBANK Cefuroxime
drug DRUGBANK Silver
drug DRUGBANK Sulfathiazole
disease IDO process
disease MESH tonsillitis
disease VO dose
disease VO vaccine
disease VO Comirnaty
disease IDO immunodeficiency
disease MESH Zoster
disease MESH Toxoplasmosis
pathway KEGG Toxoplasmosis
disease IDO bacteria
disease MESH Rubella
disease VO time
disease MESH herpes simplex
disease MESH ulcerative colitis
disease MESH celiac disease
disease MESH cyclic neutropenia
disease MESH leukemia
disease MESH gastrointestinal disorders
disease IDO susceptibility
disease IDO cell
drug DRUGBANK Filgrastim
disease IDO symptom
disease VO effective
disease MESH diphtheria
disease MESH tetanus
disease MESH pertussis
pathway KEGG Pertussis
disease MESH polio
disease MESH lichen planus
disease MESH hepatitis
pathway KEGG Apoptosis
disease IDO host
drug DRUGBANK Angiotensin II
disease IDO production
disease MESH autoimmunity
disease MESH oxidative stress
disease MESH DNA damage
disease MESH inflammation
disease VO mouth
drug DRUGBANK Oxygen
drug DRUGBANK Leptin
disease VO Fungi
disease MESH influenza
disease VO Salmonella
disease MESH lymphadenopathy
disease MESH genital herpes
disease IDO infectious agent
disease MESH vulvar cancer
disease MESH high grade squamous intraepithelial lesions
disease MESH carcinoma
disease MESH HPV infections
disease VO efficient
disease MESH convalescence
disease VO age
disease MESH melanoma
pathway KEGG Melanoma
drug DRUGBANK Bismuth subgallate
disease IDO algorithm
disease VO report
drug DRUGBANK Nonoxynol-9
drug DRUGBANK Cefradine
disease VO adverse event
disease MESH squamous carcinoma
disease VO cancer

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